Words similar to tumorigenicity

Example sentences for: tumorigenicity

How can you use “tumorigenicity” in a sentence? Here are some example sentences to help you improve your vocabulary:

In a tumorigenicity model using human fibroblast cells, the loss of wild-type p53 and transfection of activated ras led to increased VEGF expression (Devavrata et al.
This is consistent with previous observations that M6P/IGF2R knockout mice displayed generalized increased growth and cardiomygaly (resulting from cardiac myocyte hyperplasia) [ 34 ] , and that antisense-mediated reduction of M6P/IGF2R expression enhances tumorigenicity in JEG-3 cells [ 43 ] . Thus, loss or mutation of M6P/IGF2R may contribute to development and progression of tumors via different pathways: by increasing the mitogenic activity of IGF-II and decreasing the apoptotic signaling of TGF-β and lysosomal proteases.
It is probable, however, that like tumorigenicity suppressor genes and oncogenes many more genes involved in metastasis remain to be discovered since the process is complex, involving a large number of pathways [ 4 ] . Most of the known genetic mechanisms involved in the progression of a tumor to the metastatic state involve the loss of function of genes that prevent cells from becoming invasive.
Anchorage independence analysis and tumorigenicity
An increasing amount of data suggests that the RAR-β isoform, which is under the transcriptional control of RAR-α, is involved in suppressing cell growth and tumorigenicity [ 11, 12, 13, 14, 15, 16].