Words similar to tumorigenesis
Example sentences for: tumorigenesis
How can you use “tumorigenesis” in a sentence? Here are some example sentences to help you improve your vocabulary:
To investigate the role of promoter methylation in detail in cervical tumorigenesis, we evaluated CpG methylation of 16 genes in 90 CC specimens and cell lines.
MCF7 and T-47D cells express variable BP1 levels and are tumorigenic only in the presence of estradiol [ 26 27 ] . BP1 expression might therefore be involved in tumorigenesis in mice.
In some circumstances, CD4 +and CD8 +T cells were rendered inactive in tumor-bearing hosts [ 8 ] . The inactivation of CD4 +T cells has been attributed either to the tumor cells themselves or to bone marrow-derived cells [ 9 10 11 ] , whereas antigen ignorance or loss of memory have been postulated to underlay that of CD8 +T cells [ 12 13 ] . Other studies have suggested that tumor cells can secrete immunosuppressive factors such as TGF-β or express Fas ligand to induce apoptosis of infiltrating lymphocytes [ 14 15 16 ] . Furthermore, the tumor vasculature appears to be quite different from normal blood vessels, in terms of structural organization, interstitial pressure, and flow patterns [ 17 ] , and in reduced lymphocyte and natural killer cell homing and adhesion [ 18 19 20 21 ] . The existence of significant barriers to effective immunological destruction is further illustrated by a mouse model of concurrent multistage tumorigenesis and anti-oncogene autoimmunity, wherein progenitor dysplastic lesions are infiltrated and disrupted, while solid tumors are not [ 22 ] . The hypothesis is that the microenvironment of certain types of solid tumor can serve to locally suppress T cell infiltration.
The NMU-induced rat model of mammary tumorigenesis is widely used for chemoprevention studies, and yields rapid development of hormonally responsive mammary tumors with 100% incidence [ 2, 4, 18].
In conclusion, we have shown that treatment of rats with tamoxifen or retinoids results in effective chemoprevention of mammary tumorigenesis, without any detectable effect on local expression of TGF-βs.
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