Words similar to tumor-associated
Example sentences for: tumor-associated
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In addition, eight tumor-associated stromal components (including fibroblasts, endothelial cells and inflammatory cells) were microdissected from primary tumors without known metastases for analysis.
TSP-1 is a homotrimeric multidomain glycoprotein synthesized and secreted by numerous cell types, including platelets, vascular smooth muscle cells and keratinocytes [ 4 ] . Due to its interaction with a wide variety of proteins, TSP-1 has been implicated in a number of biological processes including coagulation, cell adhesion, the modulation of cell-cell and cell-matrix interactions, control of tumor growth and metastasis, and angiogenesis [ 10 ] . Inhibition of tumor cell proliferation has been achieved in vivo by systemic treatment with TSP-1 peptide mimetics [ 11 ] , but a correlation between primary tumor TSP-1 expression and poor prognosis has not been clearly established [ 12 ] . While there are reports that these molecules can originate from tumor cells [ 13 ] , the majority of reports have suggested that the major source of both TSP-1 and OPN is tumor-associated stroma [ 14 ] or infiltrating macrophages and lymphocytes [ 15 ] .
The total number of samples studied using LCM and qPCR were 76 (68 samples were microdissected to specifically enrich for cells of epithelial origin, and eight samples were microdissected to obtain tumor-associated stroma).
The cells of interest in the majority of cases were those of epithelial origin, but eight specimens were also used for the isolation of tumor-associated stroma (fibroblast, endothelial and inflammatory cells) for comparison.
Several articles describe the identification of genes associated with the activation of ECs and angiogenesis, as well as the repertoire of genes expressed in normal versus tumor-associated endothelium [ 42 43 44 45 ] . Because EC activation is a complex process, accompanied by alterations in many aspects of EC physiology, it was not surprising that the genes identified in these studies were in several functional classes.
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