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Example sentences for: tsds

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Furthermore, of the 1,687 full-length L1 elements that lack this insertion, 1,233 (73%) have TSDs, whereas only 1,071 (55%) of those that have the extra sequence have recognizable TSDs; the reduced frequency of TSDs further suggests that L1s with the 131-nucleotide insertion in their 5' UTR represent an older class of insertions.
We have previously found that nearly 9% of recent L1 insertions in the human genome have TSDs that are consistent with 3' transduction [ 23 ] . That is, the 3' TSD of these L1s with transduction-derived sequence (L1-TDs) is preceded by a poly(A) tail and located up to several hundred nucleotides downstream from the end of the L1 3' UTR [ 35 36 ] . On the other hand, standard L1 insertions have TSDs that follow a poly(A) tail immediately flanking the L1 sequence.
TSDs were required to be at least nine nucleotides long.
To facilitate this study, we wrote the software TSDfinder, which identifies the TSDs, poly(A) tails, and inversion breakpoints (if any) associated with L1s.
Using this algorithm, we collected from the human genome sequence those L1s with recognizable TSDs.