Words similar to tsds
Example sentences for: tsds
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This finding, combined with generally high TSD scores and manual inspection of hundreds of L1s recovered, gives us confidence that the sequences identified by the TSDfinder algorithm represent actual TSDs.
This 3' sequence becomes transduced, along with the L1 sequence, to a new genomic locus; a hypothesized cause of the imprecision of the 3' end of the L1 transcript is the weak polyadenylation signal in the L1 element [ 28 ] . Clear indications of 3' transduction have been documented in cases where an L1 inserted into the dystrophin gene [ 29 ] , APC [ 30 ] and CYBB [ 31 ] . All these disease-producing L1 insertions, the boundaries of which were defined by flanking TSDs, contained novel sequences downstream of the L1 sequence itself.
Ten nucleotides upstream and downstream of the TSDs were included in the logos.
An important step for the validation of TSDfinder results was the analysis of the TSDs identified by the algorithm.
As seen in Figure 2, the majority of TSDs identified by TSDfinder had high TSD scores (the scoring system is described in Materials and methods), with an average score of 117 out of a maximum possible score of 140.