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Example sentences for: tsds

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In cases where multiple TSDs were identified, TSDs with the best score and with a candidate poly(A) tail immediately preceding the 3' HSP were defined as the TSD for a particular L1 insertion.
To facilitate this study, we wrote the software TSDfinder, which identifies the TSDs, poly(A) tails, and inversion breakpoints (if any) associated with L1s.
Of these, 10,088 (14%) had TSDs immediately flanking the L1 element, and thus represented standard insertion events, and 6,178 (9%) had TSDs consistent with 3' transduction.
The histogram of start positions of all L1s with TSDs is shown in Figure 4. There is a clear dominance of significantly truncated L1 elements whose 5' end lies in the last 1,000 nucleotides of the L1.
We have previously found that nearly 9% of recent L1 insertions in the human genome have TSDs that are consistent with 3' transduction [ 23 ] . That is, the 3' TSD of these L1s with transduction-derived sequence (L1-TDs) is preceded by a poly(A) tail and located up to several hundred nucleotides downstream from the end of the L1 3' UTR [ 35 36 ] . On the other hand, standard L1 insertions have TSDs that follow a poly(A) tail immediately flanking the L1 sequence.