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Example sentences for: tsao
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However, in light of our recent findings implicating this loop region of p51 as a critical structural element supporting the catalytic functions of p66, it seems feasible that mutation at position 138 in p51 effectively altered the binding of TSAO through its influence on the p66 catalytic subunit [ 14 ] .
Cys→Ser mutation at position 280 in the p51 subunit has been shown to alter the RNase H activity of the heterodimeric enzyme, indicating that this residue in the thumb subdomain of p51 plays an important role in support of the RNase H activity of p66 [ 22 ] . The emergence of a strain of HIV-1 resistant to the non-nucleoside RT inhibitor TSAO (Tertbutyldimethyl silyspiro amino oxathioledioside) displaying Glu→Lys mutation at position 138 in the p51 subunit of HIV-1 RT has also been reported [ 23 ] , thus implicating p51 to play a more direct role in drug binding and/or the enzymatic activities of HIV-1RT.
The finding of significant transmission distortion of marker alleles centromeric to PARP in the Minnesota collection suggests the possibility that the disequilibrium initially reported for PARP alleles may be due to more extensive disequilibrium - to include the PARP marker - in the families studied by Tsao and her colleagues compared with other populations and groups of families studied.
After the identification of the syntenic region in mouse ( Sle1 ) as a susceptibility interval for murine SLE [ 9], a targeted study by Tsao et al [ 10] was the first to implicate this locus in human SLE (marker D1S229; P <0.
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