Words similar to triphosphatases
Example sentences for: triphosphatases
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Thus, we suspect that all fungal species will have metal-dependent RNA triphosphatases resembling those of S. cerevisiae, C. albicans and S. pombe.
The key question is whether RNA triphosphatase is a valid drug target in other fungal species besides Saccharomyces cerevisiae (which is not a human pathogen) and whether a mechanism-based inhibitor of one fungal RNA triphosphatase could be expected to display broad spectrum activity against triphosphatases from other fungal species.
To address these issues, we have characterized the RNA triphosphatases of two other fungi, including the human pathogen Candida albicans and the fission yeast Schizosaccharomyces pombe [ 10 11 12 ] . The fungal triphosphatases, S. cerevisiae Cet1, C. albicans CaCet1 and S. pombe Pct1, belong to a new family of metal-dependent phosphohydrolases that embraces the triphosphatase components of DNA virus and protozoan mRNA capping systems [ 1 7 13 14 ] . The defining features of the metal-dependent RNA triphosphatases are two glutamate-containing motifs that are required for catalysis and comprise the metal-binding site in the crystal structure of S. cerevisiae Cet1.
Further iterations, run to convergence, recovered the soluble mammalian thiamine triphosphatases (3 × 10 -4), and the N-terminal region of E. coli YgiF.
Here we have shown that the RNA triphosphatases Pct1 and CaCet1 are essential for viability of S. pombe and C. albicans, respectively The conclusion that CaCet1 is essential is based on a finding that none of the 54 independent isolates in the single-transformation test were homozygous for cacet1Δ; our interpretation is consistent with criteria established by Mitchell and colleagues for inference of essentiality using this genetic approach.
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