Words similar to triphosphatase

Example sentences for: triphosphatase

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Cryostat sections of flash frozen muscle were stained with hematoxylin and eosin, the modified Gomori trichrome stain, and for succinate dehydrogenase, cytochrome c oxidase activity, reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase, and adenosine triphosphatase (ATPase) activities at pH 4.3 and 4.6.
These results show that the pct1Δ and pce1Δ strains are viable if the chromosomal deletions are complemented by an extrachromosomal triphosphatase or guanylyltransferase gene.
The yeast triphosphatase has a novel tertiary structure in which the active site is situated within a topologically closed hydrophilic tunnel composed of 8 antiparallel β strands, which are conserved in CaCet1 and Pct1 [ 2 ] . Mutational analysis of Cet1 has identified 15 individual side chains within the tunnel that are important for Cet1 function in vitro and in vivo [ 7 8 9 ] . Each of the 8 strands contributes at least one functional group to the active site.
However, the atomic structures and catalytic mechanisms of the fungal and mammalian RNA triphosphatases are completely different [ 2 3 ] . Thus, it has been suggested that RNA triphosphatase is a promising target for antifungal drug discovery [ 2 ] .
The finding that the RNA triphosphatase CaCet1 is essential in the pathogenic fungus C. albicans provides impetus for the discovery of compounds that inhibit CaCet1 activity.