Words similar to transactivator

Example sentences for: transactivator

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In addition, BRCA1 can act as a transcriptional transactivator in yeast reporter assays [ 26, 27] and binds the RNA polymerase II holoenzyme, a component of the basal transcription machinery [ 25].
pUHD172-1neo [ 25 ] encodes the reverse tetracycline transactivator protein fused with a nuclear localization signal (rtTA-nls).
Initial results showed that CAR is an apparently constitutive transactivator able to activate gene expression in the absence of exogenously added ligands [ 8 9 ] . The first CAR ligands identified, androstanol and androstenol, are inverse agonists that block this constitutive transactivation [ 10 ] . More recently, it has been found that CAR mediates the characteristic response of a subset of drug metabolizing enzymes to a variety of structurally unrelated foreign compounds [ 11 ] . These xenobiotic activators are referred to as "phenobarbital (PB) - like," based on the prototypic effects of the anti-epileptic agent on drug metabolism [ 12 13 14 ] . The most potent activator of murine CAR is the high affinity agonist ligand TCPOBOP (1,4-bis [2-(3,5-dichloropyridyloxy)]benzene) [ 15 16 ] .
The transcriptional transactivator (Tat) is a key regulatory protein of HIV.
An 11-amino-acid-long acidic domain from the RelA subunit of NFκ-B is capable of minimal activating behavior when fused to the Gal4 DNA-binding domain (Gal4BD) [ 23 ] . The sequence, when joined together in tandem arrays, is as potent as the wild type RelA transactivator.