Words similar to transactivate
Example sentences for: transactivate
How can you use “transactivate” in a sentence? Here are some example sentences to help you improve your vocabulary:
The interaction of Tat with p300/CBP and P/CAF stimulates its ability to transactivate LTR-dependent transcription, while Tat-TAF II 250 or Tat-Tip60 interactions control the transcription of cellular genes.
Co-transfecting USF1 had no significant effect on C/EBPβ-mediated induction, but USF2a (1:1, USF2a:C/EBPβ expression vectors) reduced induction by 60%, indicating that USF2a may interrupt the ability of C/EBPβ to transactivate the RIIβ promoter.
Therefore, Elk-1 and p35-C/EBPβ are working synergistically to transactivate the reporter construct in the presence of SRF.
C/EBP is previously reported to be an important accessory factor for transactivation by several other transcription factors [ 26 ] . C/EBPβ was shown to transactivate the α1-acid glycoprotein gene promoter even when mutated in the DNA-binding domain, and this activation appeared to depend on protein-protein interaction with glucocorticoid receptor through the leucine zipper region [ 27 ] . Recently, a conserved domain in C/EBPα and C/EBPβ was shown to mediate cAMP responsiveness, strengthening the fact that C/EBP may be characterized as a cAMP-responsive nuclear regulator [ 28 29 ] . On the COX-2 promoter in granulosa cells, cAMP-mediated regulation was shown to be mediated primarily by an E-box that bind USF1 and USF2 isoforms in a manner resembling the RIIβ E-box in Sertoli cells [ 30 ] . Transactivation of the COX-2 gene in skin carcinoma cells is highly dependent on this E-box together with a C/EBP binding site that bind C/EBPβ and C/EBPδ [ 31 ] . These data strengthens a model of formation of a cAMP-responsive unit (CRU) containing USF and C/EBP.
Due to the common observations that both Elk-1 and p35-C/EBPβ transactivate the SRE, interact with SRF, and are responsive to Ras-dependent signaling pathways, we hypothesized that Elk-1 and p35-C/EBPβ may both be necessary for maximal induction of SRF dependent transcription.
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