Words similar to transactivation

Example sentences for: transactivation

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Released NF-κB dimers then translocate to the nucleus, bind to its cognate DNA elements, and induce the expression of target genes [ 23 24 25 ] . Activated, nuclear translocated, NF-κB transcription factor has been documented in the mouse embryo from the 1-cell stage onward [ 26 27 ] . Activated NF-κB translocation into the nucleus, directly or indirectly, effects the transcriptional control of over 150 target genes [ 28 ] . NF-κB enhances cell proliferation by stimulating the expression of cytokines such as TNF, IL-1, IL-2, IL-6, and IL-8, among others [ 28 29 ] ; NF-κB inhibits apoptosis by inducing TRAF and clAP expression which suppresses Caspase 8 activation [ 30 ] , and by inhibition of p53 transactivation [ 31 32 ] .
In unstimulated cells, the mdm2 protein binds to the N-terminal transactivation domain of p53 and targets it for ubiquitin-dependent degradation [ 6, 7].
These results suggest a new mechanism for transactivation of the SRE, where a competent transcriptional complex consisting of at least SRF, TCF, and p35-C/EBPβ participate in transactivation in response to Ras.
On the βRARE, for example, the RXR agonist might bind, but not increase transactivation beyond that observed in the absence of ligands.
Initial functional results suggested that transactivation by CAR/RXR heterodimers is not affected by RXR ligands, including 9-cis-RA or synthetic rexinoids, indicating that CAR is a non-permissive RXR partner.