Example sentences for: transactivation

How can you use “transactivation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • p38 and p35-C/EBPβ both contain an N-terminal transactivation domain and a C-terminal DNA binding/dimerization domain.

  • Conversely, introduction of full-length BRCA1 by retrovirus-mediated gene transfer inhibited growth of breast and ovarian cancer cell lines in both in vitro and in vivo experiments [ 51], and transfection of BRCA1 into colon cancer cells inhibited new DNA synthesis by 50% in addition to inhibition of S-phase progression, possibly through direct transactivation of the cell cycle inhibitor p21 WAF1/CIP1[ 49].

  • Each gene may express several different isoforms because of alternative splicing and differential promoter usage [ 2 ] . Both the RARs and RXRs contain functional domains for DNA and ligand binding, dimerization with other transcription factors, and transactivation of RA responsive promoters.

  • p20-C/EBPβ encodes the 20 kDa form of C/EBPβ, which lacks the N-terminal transactivation domain of the longer p35-C/EBPβ isoform.

  • In the RARα amino terminus, a consensus mitogen activated protein kinase (MAPK) phosphorylation sequence was found to be a target of cyclin H and cdk7 [ 7 ] . RARα was shown to bind the cyclin H/cdk7 complex in vitro and phosphorylation of serine 77 enhanced the transactivation function of RARα.


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