Example sentences for: transactivation

How can you use “transactivation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • FUNG and FISH may decrease Apoa4 expression through PPARα [ 76 77 ] , and in the current experiment, LC-PUFA may have affected PPARα transactivation and signaling.

  • The functional activity of Tat1-72 was confirmed using a transactivation assay in HL3T1 cells containing an HIV-1 LTR-CAT construct [ 33].

  • The S77A mutant receptor was shown to inhibit ligand dependent transactivation of RA responsive promoters [ 7 ] , but the mechanism of this reduction (e.g.

  • The highly acidic carboxy-terminal (BRCT) region of BRCA1 has been suggested to play a role in transactivation [ 11 ] . BRCT interacts with BRCA2, Rad51, other tumor suppressing elements, as well as numerous transcription factors, such as RNA helicase A and STAT1 [ 15 16 ] . Recently, it has been discovered that truncation of this region resulted in suppression of apoptosis following pro-apoptotic stimuli [ 17 ] . Further, these studies also suggested that the BRCT region facilitates apoptotic functions within the caspase pathway.

  • Conversely, introduction of full-length BRCA1 by retrovirus-mediated gene transfer inhibited growth of breast and ovarian cancer cell lines in both in vitro and in vivo experiments [ 51], and transfection of BRCA1 into colon cancer cells inhibited new DNA synthesis by 50% in addition to inhibition of S-phase progression, possibly through direct transactivation of the cell cycle inhibitor p21 WAF1/CIP1[ 49].


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