Words similar to transactivating
Example sentences for: transactivating
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An NMR structure for the lexA DNA-binding domain has been presented [ 26 ] . The structure is compact and globular, and probably interferes only minimally with fused transactivating sequences.
As previously reported, the full-length LAP-form of C/EBPβ induced the RIIβ promoter 5-6-fold, whereas the C/EBPβ LIP-form lacking the transactivating region had no effect.
USF1 and USF2 display identical dimerization and DNA binding domains, but the transactivating regions differ [ 25 ] . USF1 and USF2 obviously serve different, yet overlapping functions, and regulating the relative USF1/USF2 levels may be decisive for the pattern of USF-mediated gene expression, which has been shown in studies of USF knockout mice.
Stat3 also contains in its N-terminus one of this motifs ( 221LAGLL 225) [ 39 ] . Moreover, Stat3 also presents a Ser at -2 position of the LXXLL sequence, which in the case of the coactivator TRBP defines selectivity for nuclear receptors [ 40 ] . Phosphorylation of Stat3 has been reported to occur only in 705Tyr and in 727Ser, allowing dimerization and full transactivating activity [ 41 ] . Whether this 219Ser next to the LXXLL motif is involved in the coactivator activity of Stat3, and the interaction of Stat3 with other coactivators only takes place in the context of Stat3 transcription factor activity or also can be part of the general mechanism of the transcription complex formation requires further studies.
and, (ii) what is the significance of the extreme sequence diversity evidenced by transactivating peptides?
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