Words similar to tpr
Example sentences for: tpr
How can you use “tpr” in a sentence? Here are some example sentences to help you improve your vocabulary:
For an ideal test in which FPR = 0 and TPR = 1, the region would encompass all subjects with cancer but no subjects without cancer.
Protein phosphatase 5 has been implicated in the control of cell proliferation, in hormonal signal transduction, and in hsp90 chaperone function [ 3 11 12 13 14 15 16 17 ] . However little is known about the regulation of PP5 or its specific role in these pathways, and only one physiological substrate for PP5 has been identified to date, the apoptosis signaling kinase ASK 1 [ 13 ] . PP5 can be activated by lipid in vitro , and removal of the TPR domain or the C terminus generates an active, lipid insensitive form of the enzyme [ 18 19 20 21 ] . PP5 phosphatase activity is also altered by hCRY2 and a fragment of hsp90 in vitro [ 21 22 ] . These findings suggest that PP5 may be autoinhibited and that the binding of protein partners or lipids to the TPR domain could potentially control PP5 activity in cells, however no reports have yet documented how PP5 is regulated in vivo . The activity of PP5 homologs from cauliflower, T. brucei and P. falciparum is stimulated by polyunsaturated fatty acids in vitro [ 7 8 9 10 ] and removal of the TPR domain from P. falciparum PP5 increases activity to the same extent as lipid treatment [ 8 9 ] . This suggests that the TPR domain plays a similar inhibitory role for all PP5 homologs.
Thus, in comparing the full sequences of the PP5s, only three of the four PfPP5 TPRs were aligned with the others, and the second TPR of PfPP5 was left out.
AA did not stimulate 32P-MBP dephosphorylation by Ppt1p after removal of the TPR domain (data not shown).
A plot of the FPR and TPR for each region would lead to a cloud of points, rather than the smooth curve in Figure 1. To create the best ROC curve, one should select those points that are highest and farthest to the left, which is generally all that would need to be presented and only for small false positive rates.
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