Words similar to tpr
Example sentences for: tpr
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1) whose side chain projects away from the TPR groove, resulted in a 10-fold elevation of basal activity, and this Glu is conserved in both Pf and Trypanosoma PP5 (Fig.
A second reason for using FPR and TPR from mammography is that, based on various randomized trials with cancer mortality endpoint, mammography is generally considered an acceptable screening modality.
In the case of mammalian PP5, results from lipid stimulation and binding, limited proteolysis and truncation studies taken together suggest the TPR domain and the C terminus inhibit PP5 activity in a coordinated manner and that lipid binding to the TPR domain activates the enzyme in vitro [ 18 19 20 ] . In the present study we used assay conditions for Ppt1p identical to those in which PP5 was shown to be activated by removal of the TPR or C-terminal regions [ 19 ] . Under these conditions Ppt1p is also stimulated by lipids toward 32P-MBP, and activating lipids slow TPR domain proteolysis.
While the catalytic core is generally necessary and sufficient for the phosphohydrolase activity of PPP enzymes, the residues outside the core play critical roles in binding accessory proteins or small molecules that modulate the catalytic activity [ 25 26 27 28 29 ] . Specifically in the PP5 class, the N-terminus has been shown to contain three TPR motifs [ 5 6 7 8 ] , the three-dimensional structure of which is now also available [ 8 ] . Interestingly, the N-terminal sequence of PfPP5 was the longest of all, and seemed to contain four TPR motifs instead of three (Fig.
The TPR motif was originally identified as a protein interaction module in the cell division cycle (CDC) proteins in yeast [ 36 37 ] but has since been shown to occur in proteins with diverse functions in a variety of species [ 9 ] . The number of the TPR domains, the spacing between them, and their placement in the primary structure of the protein appear variable, and the relative contribution of the individual TPRs in a given protein has not been studied.
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