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Example sentences for: tpr

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At least four major kinds of macromolecular complexes have been identified that involve TPR domains.
Moreover, secondary structure prediction suggested that each PfPP5 TPR also has the potential to form the two conserved helices (A and B), as marked in Fig.
The TPR motif was originally identified as a protein interaction module in the cell division cycle (CDC) proteins in yeast [ 36 37 ] but has since been shown to occur in proteins with diverse functions in a variety of species [ 9 ] . The number of the TPR domains, the spacing between them, and their placement in the primary structure of the protein appear variable, and the relative contribution of the individual TPRs in a given protein has not been studied.
When biomarker measurements occur at regular time intervals (and allowing different numbers of measurements for each subject), one can estimate TPR and FPR by using a first order Markov chain in reverse time, as described by Baker and Tockman [ 20 ] for the analysis of precancerous lesions for lung cancer.
TPR domains consist of a series of antiparallel amphipathic α helices that bundle together through hydrophobic interactions to form a cradle-shaped groove, postulated to be involved in binding a number of proteins of regulatory importance such as heat shock protein 90, a major cellular chaperone [ 8 9 10 ] .