Words similar to tpr
Example sentences for: tpr
How can you use “tpr” in a sentence? Here are some example sentences to help you improve your vocabulary:
A similar change in susceptibility to proteolysis upon lipid binding was observed with PP5 [ 19 ] . As with PP5, only lipids that stimulated 32P-MBP dephosphorylation slowed degradation of the 20 kDa TPR fragment (Table 1).
AA did not stimulate 32P-MBP dephosphorylation by Ppt1p after removal of the TPR domain (data not shown).
Removal of the TPR domain prevents stimulation by lipid, but only modestly increases Ppt1p activity.
Removal of the TPR domain of PP5 by limited proteolysis increases enzyme activity and the TPR domain binds lipid [ 7 8 9 19 20 ] . Using conditions similar to those employed with PP5, digestion of Ppt1p with trypsin in the absence of lipid produced a 44 kDa catalytic fragment that was stable for at least 30 min and a 20 kDa fragment that was degraded within 30 min (Fig.
Although more work will be required to determine its role in lipid stimulation, removal of the TPR domain had only a small effect on Ppt1p activation.
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