Words similar to tprs
Example sentences for: tprs
How can you use “tprs” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although no single amino acid is absolutely invariant in all TPRs, they do contain a largely conserved pattern of amino acid similarity in terms of size, hydrophobicity, and spacing [ 8 9 ] . Eight amino acid residues are critically placed on the same face of their respective helices: 4, 8, and 11 on the first helix, and 20, 24, and 27 on the second [ 8 9 ] . As shown in Fig.
To identify whether PfPP5 is actually expressed in the parasite, cell-free extracts of the asynchronous erythrocytic stage parasites were subjected to standard chromatographic procedures that had been previously optimized for human PP5 [ 18 ] . Studies of mammalian PP5 have revealed that the TPR domain might act as an auto-inhibitory domain of the phosphatase activity, and that tryptic digestion of PP5 causes loss of the TPRs and concomitant stimulation of activity [ 19 20 21 ] . As described under Materials and Methods, the purification was in fact monitored by assaying for a trypsin-activated phosphatase with the assumption that PfPP5 may behave like mammalian PP5 in this regard [ 18 20 21 ] . As mentioned, the activity peaks always coincided with a ~69 kDa band in parallel Western analyses of the chromatographic fractions.
A detailed sequence analysis of all the PfPP5 TPRs is offered below.
2. Thus, all the TPRs of PfPP5 may satisfy the structural requirements of a TPR motif.
2, residues that are identical or have similar hydrophobicity are found in all four proposed TPRs of PfPP5 in the correct relative spacing.
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