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Example sentences for: tprs
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The TPR motif was originally identified as a protein interaction module in the cell division cycle (CDC) proteins in yeast [ 36 37 ] but has since been shown to occur in proteins with diverse functions in a variety of species [ 9 ] . The number of the TPR domains, the spacing between them, and their placement in the primary structure of the protein appear variable, and the relative contribution of the individual TPRs in a given protein has not been studied.
Although no single amino acid is absolutely invariant in all TPRs, they do contain a largely conserved pattern of amino acid similarity in terms of size, hydrophobicity, and spacing [ 8 9 ] . Eight amino acid residues are critically placed on the same face of their respective helices: 4, 8, and 11 on the first helix, and 20, 24, and 27 on the second [ 8 9 ] . As shown in Fig.
Protein phosphatase 5 (PP5), a newer member of the PPP family, differs from the other Ser/Thr phosphatases in that it contains regulatory and (sub)cellular targeting functions within a single polypeptide [ 5 6 7 ] . While its catalytic core exhibits strong similarity to those of the other members of this family, its N-terminus consists of three tetratricopeptide repeats (TPRs) that are unique to the PP5 class.
Thus, in comparing the full sequences of the PP5s, only three of the four PfPP5 TPRs were aligned with the others, and the second TPR of PfPP5 was left out.
The crystal structure of the PP5 TPR domain revealed three TPRs followed by an extended α helix [ 24 ] , however Ppt1p was originally proposed to contain one additional TPR [ 2 ] . The pattern of proteolysis and sites of cleavage for Ppt1p are very similar to those seen with PP5 under these same conditions [ 19 ] . This indicates that Ppt1p also contains an accessible region linking the TPR and catalytic domains and is most consistent with the presence of three TPRs in Ppt1p.
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