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Example sentences for: tmc
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The murine TMC protein subfamily A consists of three proteins, Tmc1, Tmc2, and the novel Tmc3.
Mutations in TMC1 are responsible for the autosomal dominant human hearing disorder DFNA36 and for the recessive deafness DFNB7/11 [ 5 ] ; the corresponding murine gene Tmc1 also causes deafness in the mutant mouse strains Beethoven ( Bth ) and deafness ( dn ) [ 6 ] . Bth / Bth mice display altered potassium currents in early postnatal cochlear hair cells, in particular Ik,n and Ik,f currents appear to be depressed [ 10 ] . This observation led to the hypothesis that Tmc1 may participate directly or indirectly in regulating the permeability of potassium channels [ 10 ] . Because of the high level of conservation of the amino acid sequences among the eight mammalian TMC proteins (Figure 1, Additional file 1), we speculate that other TMC proteins may as well be modifiers of ion channels or transporters.
The high amino acid sequence conservation of 75-96% identity among the individual human and mouse TMC proteins implies that mutations that alter the coding sequence in the corresponding genes are subjected to significant selective pressure; thus advocating that TMC proteins have important cellular roles.
The recently identified genes encoding the cochlear transcripts for TMC1 and TMC2, and encoding the proteins EVER1 and EVER2, belong to a novel gene family that is conserved in animals.
Second, our analysis of the organization of vertebrate TMC genes implied identical allocation of the individual TMCs (Figure 3and additional file 1).
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