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Example sentences for: tmcs

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All other capitalized amino acids are conserved in more than 70% of all TMCs, and lower case letters indicate the most probable amino acid residue.
The nomenclature of the pufferfish TMC genes and proteins is derived from the phylogenetic relation of the corresponding sequences with the mammalian TMCs (Figure 4).
The TMC protein family has eight members in vertebrates and forms three subfamilies, A, B, and C. TMCs are proteins with a conserved core of eight membrane-spanning domains.
On the basis of comparative structural predictions of all mammalian TMCs we propose a basic topology of the generic TMC protein with variable intracellular amino- and carboxyl-termini, a conserved core with eight membrane-spanning domains, and some variability in the length of several intra- and extracellular loops (Figure 2).
The high degree of similarity between the corresponding human and murine TMCs suggests a conserved function of these proteins.