Example sentences for: tk

How can you use “tk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The pol from HSV-2 6757, a virus which showed a 300- to 700-fold higher error rate than HSV-1 SC16 by the tk mutagenesis assay previously [ 21 ] , was found to contain three mutations compared to the other HSV-2 pols , with one change residing in region VII which is shared among diverse DNA polymerases (Fig.

  • The KK, TK, and KKTK versions of Boi1-GFP all showed a polar pattern of localization in approximately half of the unbudded cells (Fig.

  • The targeting vector also contains the HSV TK gene to allow for negative selection of non-recombinants.

  • Sequence analysis of the TK coding region from all five plaque isolates identified a G nucleotide insertion in the homopolymeric hot-spot G7 tract at nucleotide 435, a common mutation present in other ACV rHSV isolates [ 18 19 ] . This base insertion produced a frame shift in the coding sequence, resulting in a loss of the ATP / nucleoside-binding site and the creation of a premature stop codon at amino acid 228 to encode a truncated 28 kD TK polypeptide.

  • As expected, given that the TK substitutions were sufficient to severely affect pelleting with PS vesicles, none of the Boi1-PH(KKTK) was seen to co-sediment with PS vesicles (Fig.


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