Words similar to tk
Example sentences for: tk
How can you use “tk” in a sentence? Here are some example sentences to help you improve your vocabulary:
In this assay, the HSV-2 Pol does not appear to be solely responsible for the difference in drug-resistant spontaneous tk mutations observed between HSV-1 and HSV-2 strains.
An important distinguishing factor between the tk mutagenesis and LacZ test systems is the use of antiviral selectors to measure mutation frequency.
Extracellular particles of IHD-J were obtained by infecting TK -143B cells.
Cortical astrocytes were harvested from neonatal C57BL/6 mice and infected with a replication-defective retrovirus encoding Tag and neomycin resistance as previously described [ 13 ] . The transferred viruses were SV40-6 [ 5 ] , in which wild type Tag is expressed from the M-MuLV LTR promoter; SV(X)T K1, which is constructed the same as SV40-6 except that the Tag is mutant [ 38 ] and defective for binding the retinoblastoma protein family [ 39 ] ; Linker-tkT, in which the cDNA for Tag is expressed from the herpes simplex 1 tk promoter [ 11 ] . The differentiation and transformation phenotypes of the cell lines utilizing the M-MuLV LTR promoter have been described [ 6 13 ] . The Linker-tkT lines (tkT) were either isolated as clones after G418 selection (as previously described) [ 6 ] or frozen immediately after selection (pooled clones) and clonally selected at a later time.
In addition to the potential impact of target sequence and secondary structure topology on mutation frequency, other viral replicative proteins including Pol accessory protein, TK, dUTPase, and uracil-DNA glycosylase may cooperate with Pol to modulate polymerase repair and nucleotide selection [ 12 13 19 23 ] .
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