Example sentences for: tk

How can you use “tk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Two-hybrid protein-protein interaction assays were performed in Hela cells, with a reporter plasmid (pG4-TK-Luc) containing six GAL4 binding elements upstream of the thymidine kinase (TK) promoter region fused to the luciferase reporter gene (Fig.

  • The targeting vector also contains the HSV TK gene to allow for negative selection of non-recombinants.

  • However, alignment of the tk sequences showed that the type 2 gene had at least eight distinct stretches containing between 7 and 13 G-C bases, whereas the overlapping region in the type 1 tk had four or less G-C bases.

  • The demonstration of S1 nuclease-sensitive sites within the type 2 viral genome overlapping the tk coding region, and the absence of such sites in the type 1 viral genome, suggest that local topology may be different between these HSV-1 and HSV-2.

  • Thus, the high proportion of errors associated with HSV-2 viruses appears specific to the tk mutagenesis assay.


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