Words similar to thymocytes
Example sentences for: thymocytes
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For example, TN3 stage thymocytes in the Rag -/-adult thymus have proliferation levels 3-fold below wild type thymus [ 13 37 ] , while in the Rag -/-fetal thymus TN3 cells are only 25-30% lower than in wild type fetal thymus.
Total post-Ficoll un-fractionated thymocytes were incubated in the presence or the absence of 10 nM PMA and/or 0.1 mM cAMP + 1 mM of the phosphodiesterase inhibitor isobutylemthylxnthine (IBMX).
The TN1 and DP stages both show increased proliferation in wild-type fetal thymocytes compared to adults.
5 in the developing thymus, well before significant thymocyte maturation takes place [ 52 53 ] . Although the number of TECs is reduced by about 2-fold in Hoxa3 +/- Pax1 -/-compound mutants, the number of thymocytes is reduced by a slightly greater amount, around 3-fold [ 29 ] . Therefore, the reductions seen in cytokine message levels in the Hoxa3 +/- Pax1 -/-compound mutants are not secondary to decreased TEC numbers.
Most dramatically, the percentages of BrdU +cells in fetal thymocytes were 10-fold higher than in the adult at the earliest, TN1 (CD44 +25 -) thymocyte differentiation stage (P < 0.001).