Words similar to thymocytes

Example sentences for: thymocytes

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The TN1 and DP stages both show increased proliferation in wild-type fetal thymocytes compared to adults.
On the other hand, cAMP is known to participate in the growth and differentiation of varied cell types (including thymocytes), through the transcriptional regulation of specific genes [ 32 33 34 ] . The unique cAMP signaling which specifically targets the expression of the CD8 mRNAs (α and β), suggests that PKA activation may result in the transduction of signals that determine the selection of T lymphocytes in favor of the CD4 +CD8 -lineage, by down-regulating and possibly turning off the expression of the CD8 transcripts.
This results in loss of tolerace of T cells to this peptide, presumably on the basis of lack of thymic deletion of thymocytes that are reactive with this antigen.
For instance, changes in expression of CD5, TCR, Bcl-2, RAG and TdT genes can be induced by in vitro TCR engagement of DP thymocytes, thus indicating that at least some aspects in the T cell maturation program are directly coupled to TCR signaling.
1, PMA caused a marked decrease in the levels of both CD4 and CD8 mRNAs, whose constitutive expression is high in developing thymocytes.