Words similar to thymocytes
Example sentences for: thymocytes
How can you use “thymocytes” in a sentence? Here are some example sentences to help you improve your vocabulary:
Therefore, nearly every stage from the earliest TN to the DP stages showed significantly increased proliferation in fetal thymocytes relative to adults.
It is known that during clonal selection in the thymus, immature CD4, CD8 double positive cells develop into single positive CD4 or CD8 cells according to the relative affinity of their TCR to class II or class I molecules respectively [ 5 6 ] . These immature T-cells are selected in the thymic epithelium on the basis of their TCR interaction with either class I or class II MHC molecules [ 7 8 ] , thus generating two mutually exclusive subpopulations that are characterized by the expression of either CD4 or CD8 glycoproteins [ 9 ] . Earlier studies in the murine system have demonstrated that PMA and cAMP can modulate the expression CD4 and CD8 on developing thymocytes [ 10 11 12 13 ] . In keeping with these findings, ex vivo experiments with human thymocytes previously reported by our group, revealed that while phorbol esters can coordinately regulate the transcription of α and β TCR during intrathymic T cell differentiation [ 14 ] , cAMP selectively affected the transcription of the α and δ-TCR [ 15 16 ] . Together the murine data and our own findings support the hypothesis that in humans, TCR expression and CD4, CD8 commitment and selection may be regulated by the same signal-transduction pathways.
Early during T-cell development in the thymic cortex, thymocytes bear both of the T cell surface glycoproteins CD4 and CD8 and express the α and β heterodimer of the TCR [ 4 ] . Compelling data have demonstrated that CD4 and CD8 molecules participate in the selection of MHC class I or class II restricted T cells in the thymus.
These results with Rag1 -/-fetal thymocytes contrast with thymocytes in the Rag -/-adult, which have much lower proliferation than wild type adult thymocytes at all stages of thymocyte differentiation [ 13 ] .
Despite expression of levels of hCARΔcyt comparable to that of double-negative and single-positive thymocytes, double-positive thymocytes were relatively refractory to reporter expression following transduction with either the Ad5.UbP.GFP or Ad5.CMV5.GFP vector.
Loading...