Words similar to thymocytes
Example sentences for: thymocytes
How can you use “thymocytes” in a sentence? Here are some example sentences to help you improve your vocabulary:
Human thymocytes were purified from fresh residual thymic tissue that was obtained as an incidental specimen from immunologially normal pediatric patients undergoing cardiac surgery and according with institutional guidelines.
With the possible exception of double positive thymocytes (see below), reporter expression by transduced hCARΔcyt-positive cells at each of these developmental stages was very efficient.
It is known that during clonal selection in the thymus, immature CD4, CD8 double positive cells develop into single positive CD4 or CD8 cells according to the relative affinity of their TCR to class II or class I molecules respectively [ 5 6 ] . These immature T-cells are selected in the thymic epithelium on the basis of their TCR interaction with either class I or class II MHC molecules [ 7 8 ] , thus generating two mutually exclusive subpopulations that are characterized by the expression of either CD4 or CD8 glycoproteins [ 9 ] . Earlier studies in the murine system have demonstrated that PMA and cAMP can modulate the expression CD4 and CD8 on developing thymocytes [ 10 11 12 13 ] . In keeping with these findings, ex vivo experiments with human thymocytes previously reported by our group, revealed that while phorbol esters can coordinately regulate the transcription of α and β TCR during intrathymic T cell differentiation [ 14 ] , cAMP selectively affected the transcription of the α and δ-TCR [ 15 16 ] . Together the murine data and our own findings support the hypothesis that in humans, TCR expression and CD4, CD8 commitment and selection may be regulated by the same signal-transduction pathways.
The abnormal cell death and proliferation patterns in the Hoxa3,Pax1 compound mutant fetal thymocytes might be caused in part by observed reductions in the transcription levels of the cytokines IL-7 and SCF produced by TECs.
Thymocytes from line 18 were incubated with Ad5.UbP.GFP as stated above, and were evaluated by flow cytometry for their expression of CD4, CD8, and GFP (Fig.
Loading...