Words similar to thymocytes
Example sentences for: thymocytes
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With intrinsic factors, unequal amounts of cell-fate determinants are distributed into the two cells prior to their separation [ 29 ] . Among the intrinsic factors underlying asymmetric division, the interactions of the Numb differentiation-associated protein with Notch proliferation-associated signaling is the model most widely studied, ranging from bacteria, yeast, and Drosophila to mammals [ 30 ] . Mammalian cells known to exhibit asymmetric division include diverse cell types such as neuronal cells, thymocytes, and satellite cells involved in myogenesis, and the list is growing [ 29 30 31 32 ] .
1, PMA caused a marked decrease in the levels of both CD4 and CD8 mRNAs, whose constitutive expression is high in developing thymocytes.
On the other hand, cAMP is known to participate in the growth and differentiation of varied cell types (including thymocytes), through the transcriptional regulation of specific genes [ 32 33 34 ] . The unique cAMP signaling which specifically targets the expression of the CD8 mRNAs (α and β), suggests that PKA activation may result in the transduction of signals that determine the selection of T lymphocytes in favor of the CD4 +CD8 -lineage, by down-regulating and possibly turning off the expression of the CD8 transcripts.
Consistent with this idea, the positive and negative selection in the thymus of CD5-deficient mice is altered in that their thymocytes are hyperresponsive and hyperproliferative to activation induced by anti-CD3 antibodies [ 17].
During this transition, T cell precursors sequentially gain and lose cell surface expression of CD44 and CD25 markers, express the pre-T cell receptor (pTCR), and undergo β-selection [ 2 7 8 9 ] . The other transition is from CD4 +8 +DP to CD4 +or CD8 +single positive (SP) thymocytes, in which DP cells express CD3, rearrange their α-TCR, undergo positive and negative selection, and down regulate CD4 or CD8 to become functional CD8 +or CD4 +SP T cells [ 10 11 ] . In addition to functional and cell surface marker changes, each thymocyte differentiation stage is marked by characteristic changes in proliferation and apoptosis [ 12 13 14 15 16 17 18 ] .
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