Words similar to thymocyte
Example sentences for: thymocyte
How can you use “thymocyte” in a sentence? Here are some example sentences to help you improve your vocabulary:
We also analyzed two mutant strains that have either cell-autonomous ( Hoxa3 +/- Pax1 -/-) or non-cell-autonomous ( Rag1 -/-) TEC defects, with blocks at different stages of thymocyte differentiation.
Several other HMG-box proteins also play important roles in lymphocyte development [ 17 ] . Mice doubly deficient in lymphocyte enhancement factor-1 (LEF-1) and T cell factor-1 (TCF-1) have a complete block in development of T cells [ 18 19 ] , while deficiency of SRY-box containing protein 4 (SOX-4) in mice results in a lack of pro-B cell expansion and mild perturbation of thymocyte development [ 20 ] . Unlike these HMG-box proteins, however, we find that the HMG-box of TOX is more closely related to the DNA binding domain of sequence-independent HMG-box proteins.
Therefore, defects in TECs can in turn cause defects in thymocyte differentiation, proliferation, or cell death.
We recently identified a gene designated Tox (for thymocyte selection-associated HMG-box gene), encoding a novel nuclear protein that shows a highly regulated pattern of expression during thymocyte differentiation.
Our previous analysis of the Hoxa3 +/- Pax1 -/-compound mutant thymocyte phenotype showed a specific partial block at the TN to DP transition, associated with increased apoptosis at both the TN4/pre-DP and DP subsets, and a 10-fold decrease in DP cell numbers [ 29 ] . Using BrdU analysis, we compared the proliferation of Hoxa3 +/- Pax1 -/-fetal thymocytes during the TN to DP transition compared to littermate controls.
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