Example sentences for: thymocyte

How can you use “thymocyte” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Rag -/-mutants have a profound thymocyte development block at the TN3 to TN4/preDP transition [ 51 ] . During normal wild type fetal thymus development, significant DP cell development does not occur until E16.

  • We also analyzed two mutant strains that have either cell-autonomous ( Hoxa3 +/- Pax1 -/-) or non-cell-autonomous ( Rag1 -/-) TEC defects, with blocks at different stages of thymocyte differentiation.

  • For example, SCF and IL-7 have been shown to have synergistic functions [ 62 63 ] . Therefore, changes in multiple cytokines in Hoxa3 +/- Pax1 -/-mutants would be expected to have complex effects on thymocyte development that could be difficult to predict.

  • Cultures from control genotypes (wild type, Pax1 +/-, Hoxa3 +/-, Pax1 -/-) behaved as expected [ 41 42 43 44 45 46 ] , with addition of IL-7 causing an increase in the percentage of DN cells and a corresponding decrease in DP cells, while adding SCF had no significant effect on thymocyte development (data not shown).

  • 2. However, if there is extremely skewed X inactivation in the thymic dendritic cell population, a particular thymocyte may not come into contact with dendritic cells that express one of the two X chromosomes.


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