Words similar to synuclein

Example sentences for: synuclein

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Mutations in α- synuclein include three point mutations (A30P, E46K, and A53T) and multiplication of the wild-type (normal) gene.
The phenotype of patients with α- synuclein mutations varies from PD to a more diffuse Lewy body disease in which pathology is detected in the cerebral cortex and other areas of the brain.
Presumably, neurons require α-synuclein for their normal function and thus cannot simply dispense with this protein that has toxic properties, although mice in which the α- synuclein gene is knocked out have no obvious deficits (see Dauer and Przedborski [2003] for discussion).
On the detrimental side of the cell survival equation is the PD gene that was discovered first, α -synuclein . The synaptic protein encoded by this gene, α-synuclein, is prone to aggregation, and, as is the case for other aggregating proteins, mutations in α- synuclein are associated with dominantly inherited disease.
We confirmed the enriched expression of the following genes: a transcription factor NGFI-A, a putative four repeat ion channel, a vesicle associated calcium/calmodulin binding protein that is homologous to CAMK IV, a neuronal calcium sensor protein hippocalcin, synuclein beta, and an EST gene.