Example sentences for: synuclein

How can you use “synuclein” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This is probably because ANOVA retains information about the experimental design; for the example of synuclein given in the results, it 'knows' that there is a large disagreement between two matched replicates in the midbrain samples, whereas the template match based on the correlation coefficient considers all variations to be essentially equivalent.

  • Mutations in α- synuclein include three point mutations (A30P, E46K, and A53T) and multiplication of the wild-type (normal) gene.

  • Presumably, neurons require α-synuclein for their normal function and thus cannot simply dispense with this protein that has toxic properties, although mice in which the α- synuclein gene is knocked out have no obvious deficits (see Dauer and Przedborski [2003] for discussion).

  • The phenotype of patients with α- synuclein mutations varies from PD to a more diffuse Lewy body disease in which pathology is detected in the cerebral cortex and other areas of the brain.

  • On the detrimental side of the cell survival equation is the PD gene that was discovered first, α -synuclein . The synaptic protein encoded by this gene, α-synuclein, is prone to aggregation, and, as is the case for other aggregating proteins, mutations in α- synuclein are associated with dominantly inherited disease.


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