Words similar to synthase
Example sentences for: synthase
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This would seem especially true in the current set of experiments, since the modulation of Thymidylate Synthase expression is known to greatly affect thymidine levels and cell growth [ 32 ] . For example, E. coli that are starved for thymine quickly die, a phenomenon known as 'thymineless death' [ 33 ] . In this respect, Group I aptazymes that may have yielded lower amounts of functional Thymidylate Synthase (e.g.
The PPARγ agonist, 15d-PGJ 2 , functions as a general inhibitor of microglial functions [ 56 57 58 ] . For example, this agent inhibits the expression of inducible nitric oxide synthase, tumor necrosis factor-α, interleukin-1 β and major histocompatibility complex class II in activated microglia.
In the liver, intestine, adipose, and mammary gland, the cytoplasmic form synthesizes acetyl CoA for lipogenesis [ 46 ] . It is regulated by SREBP-1a, -1c- and -2, as well as SP1 and SP3 binding to GC-boxes; the promoter also contains an E-box [ 47 ] . It is down regulated with fasting, and induced with re-feeding; such dietary regulation does not exist in SREBP-1 knockout mice [ 48 ] . More generally, acyl CoA synthase is reported to be PPARα-activated [ 49 ] . The observed down regulation is consistent with less acetyl CoA available for the ACC reaction, as well as a plethora of other reactions.
Of course, a more widespread perturbation of ion channel regulation in the absence of CFTR is also a possibility, as CFTR has been demonstrated to be a master regulator of such diverse proteins as the Na/K pump [ 41 ] , the basolateral Na/K/2Cl co-transporter [ 42 ] , and the inducible nitric oxide synthase [ 43 ] .
Nematodes are believed to be unique among animals in utilizing the glyoxylate cycle to generate carbohydrates from the beta-oxidation of fatty acids (reviewed in [ 46 ] ). The glyoxylate pathway, generally found in plants and microorganisms, is similar to the citrate cycle, but relies on two critical enzymes, malate synthase and isocitrate lyase, to bypass two decarboxylation steps.
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