Words similar to suppressors
Example sentences for: suppressors
How can you use “suppressors” in a sentence? Here are some example sentences to help you improve your vocabulary:
The cold sensitivity of the ALM migration defect may be useful for identifying genetic suppressors of the migration defect.
Mutations in unc-129 , a member of the transforming growth factor β (TGFβ) superfamily, were identified as genetic suppressors of ectopic UNC-6 signaling [ 7].
These aforementioned studies and other research support the idea that events affecting tumor suppressors can occur early and that preinvasive DCIS can be a direct precursor of invasive carcinoma, a paradigm supported pathologically by the frequency of DCIS lesions found in areas adjacent to invasive breast cancer [ 10].
More recent observations support an alternative mechanism of action for the PrlA/SecY and PrlG/SecE suppressors [ 8 12 ] . First, PrlA/G-mediated suppression does not exhibit allele specificity; all prlA and all prlG alleles that have been examined suppress all signal sequence mutations, implying that suppression is not due to a specific altered interaction that allows recognition of a mutant signal sequence [ 8 12 ] . Furthermore, all of the prlA and prlG alleles suppress complete deletions of the signal sequence, suggesting that an interaction between the signal sequence and the Prl suppressor is not necessary for suppression or even for export [ 5 8 13 ] . Based on these observations, it was proposed that the PrlA and PrlG suppressors do not function through altered interactions with signal sequences, but rather by loss of recognition [ 8 12 ] . The wild type SecE and SecY proteins are thought to function in concert to proofread the signal sequence of secretory proteins, rejecting defective precursors from the export pathway.
To determine whether other suppressors or enhancers might be isolated, we tested if deficiencies on the third chromosome uncover other potential interacting genes.
Loading...