Words similar to suppressors
Example sentences for: suppressors
How can you use “suppressors” in a sentence? Here are some example sentences to help you improve your vocabulary:
The PrlA (SecY) and PrlG (SecE) suppressors are compromised in their ability to proofread, allowing export of proteins with mutations, or even complete deletions, of the signal sequence.
In fact, all of the PrlA and PrlG suppressors are completely dependent on functional SecB for manifestation of suppressor activity [ 5 8 ] . Even certain proteins that are not normally SecB-dependent for translocation become SecB-dependent when they contain a signal sequence mutation and are exported via the suppressor pathway.
The signal sequence is crucial for efficient translocation; mutations in the signal sequence significantly reduce export of the preprotein and complete deletions of the signal sequence eliminate essentially all export [ 5 6 7 8 ] . Selection for extragenic suppressors of such export defective preproteins led to the identification of the prl alleles of secY ( prlA ), secE ( prlG ), secA ( prlD ), and more recently secG ( prlH ) [ 6 9 10 11 ] . Early hypotheses predicted that the Prl suppressors function by expanded or altered interactions with signal sequences, facilitating recognition of mutant as well as wild type signal sequences [ 6 ] .
To determine whether other suppressors or enhancers might be isolated, we tested if deficiencies on the third chromosome uncover other potential interacting genes.
Other mechanisms that may participate in the RU 486-induced inhibition of hepatic apoptosis include the fact that this compound blocks the inhibitory effect of glucocorticoids on suppressors of cytokine signalling in the liver [ 8 ] . This family of proteins is induced by growth hormones and cytokines, and is strongly repressed in vivo by glucocorticoids [ 8 ] . Up-regulation of these proteins by RU 486 [ 8 ] , coupled with significant increase in hepatic TNFα level found in animals treated with RU 486 [ 12 ] , may contribute to the inhibition of apoptosis observed in our study (Fig 1B).
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