Words similar to suppressors
Example sentences for: suppressors
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More recent observations support an alternative mechanism of action for the PrlA/SecY and PrlG/SecE suppressors [ 8 12 ] . First, PrlA/G-mediated suppression does not exhibit allele specificity; all prlA and all prlG alleles that have been examined suppress all signal sequence mutations, implying that suppression is not due to a specific altered interaction that allows recognition of a mutant signal sequence [ 8 12 ] . Furthermore, all of the prlA and prlG alleles suppress complete deletions of the signal sequence, suggesting that an interaction between the signal sequence and the Prl suppressor is not necessary for suppression or even for export [ 5 8 13 ] . Based on these observations, it was proposed that the PrlA and PrlG suppressors do not function through altered interactions with signal sequences, but rather by loss of recognition [ 8 12 ] . The wild type SecE and SecY proteins are thought to function in concert to proofread the signal sequence of secretory proteins, rejecting defective precursors from the export pathway.
Mutations in unc-129 , a member of the transforming growth factor β (TGFβ) superfamily, were identified as genetic suppressors of ectopic UNC-6 signaling [ 7].
Other mechanisms that may participate in the RU 486-induced inhibition of hepatic apoptosis include the fact that this compound blocks the inhibitory effect of glucocorticoids on suppressors of cytokine signalling in the liver [ 8 ] . This family of proteins is induced by growth hormones and cytokines, and is strongly repressed in vivo by glucocorticoids [ 8 ] . Up-regulation of these proteins by RU 486 [ 8 ] , coupled with significant increase in hepatic TNFα level found in animals treated with RU 486 [ 12 ] , may contribute to the inhibition of apoptosis observed in our study (Fig 1B).
These frequencies suggest that alterations on chromosome 18p occur more often in the presence of alterations affecting regions containing such tumor suppressors as p16 (9p) [ 17] and p53 (17p) [ 18], while events on chromosomes 13q, 16q and 11p occur more independently.
Glucocorticoids produce a receptor-mediated inhibitory effect on both basal and hormone-stimulated expression of a newly discovered family of molecules known as suppressors of cytokine signalling [ 8 ] . These molecules play an important role in shutting off cytokine action [ 8 ] , and RU486 may therefore augment cytokine-mediated effects.
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