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Example sentences for: stabilizing
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We assume that the effects on sleep we observed in cry1 , 2 -/-mice are a result of a lack of cryptochrome -dependent inhibition of the transcriptional activation provided by the bHLH-PAS heterodimers CLOCK:BMAL1 and NPAS2:BMAL1 [ 19 20 37 ] , although cryptochromes also play a role in stabilizing and nuclear sequestration of PER proteins [ 38 ] , and in photoreception [ 39 ] . Lack of cryptochromes results in increased mRNA levels of CLOCK/NPAS2:BMAL1 target genes, including the circadian genes per1 and per2 [ 20 23 ] . The expression of these two genes is viewed as a state variable of the molecular circadian clock or a marker of CLOCK/NPAS2:BMAL1-induced transcription, although at least per1 transcription can also be (rapidly) induced by light [ 40 41 ] , through a CREB-dependent signaling pathway [ 42 43 44 ] . The observation of high brain levels of per1,2 transcripts under baseline conditions in cry1,2 -/-mice raises the possibility that these or other CLOCK/NPAS2:BMAL1 target genes are involved in the homeostatic regulation of sleep.
Early recognition of the contrast between the stabilizing influences of density-dependent population regulation, and potentially de-stabilizing influences of environmental variation [ 1 ] , laid a foundation for theoretical modeling of population stability in stochastic environments [ 2 ] that assumes renewed relevance in light of current developments in ecology and climate research [ 3 ] . Recently, for instance, numerous studies have documented the influences of global-scale climatic variation on the population dynamics of vertebrates in widely diverse ecosystems (see, e.g., [ 4 5 ] for reviews), including species interactions at the community level [ 6 7 8 ] . To our knowledge, however, no study has yet documented a simultaneous and direct influence of large-scale climate on the dynamics at all trophic levels in a single system.
Camptothecin (CPT) and its derivatives specifically target Topo I by binding noncovalently to these cleavable complexes, stabilizing them and interfering with DNA religation [ 11].
Thus, to further test the adaptive hypothesis we compared the level of sequence divergence within the LTR and its flanking intronic sequence between the two sibling species Drosophila melanogaster and Drosophila mauritiana . If the LTR-containing intron is under stabilizing selection, a lower than neutral rate of substitution would be expected.
It significantly eases the regulatory burdens on offering participants by eliminating the trading restrictions for underwriters of activelytraded securities of large issuers, reducing the restricted periods for other securities, providing a more flexible framework for stabilizing transactions, expanding the securities eligible for Nasdaq passive market making during an offering, and deregulating rights offerings.
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