Words similar to stabilizes
Example sentences for: stabilizes
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The α subunit further stabilizes this cleft, whereas the ω subunit interacts with the β' subunit [ 7 ] . Given their ubiquitous presence in all cellular life forms and high level of sequence conservation, it seems evident that the core subunits of this complex RNA synthesis machine were already present in the last universal common ancestor (LUCA) of the extant cellular life forms and performed functions mechanistically similar to those of modern DDRP.
Furthermore, the gain-of-function Smo mutation renders the protein less sensitive to the inhibitors, presumably because the amino-acid substitution directly stabilizes or induces an active conformation.
However, the addition of proteasome inhibitor LLnL stabilizes the interaction (Fig.
The two flaps fold over the inhibitor to form a tunnel-shaped active site and are held in this close position by hydrogen bonding from Ile50 and Ile50' NH groups of the enzyme to a water molecule, which in turn is hydrogen bonded to the P2 and P1' CO groups of the inhibitor [ 24 ] . The bonding stabilizes the flaps in a closed position and inhibits the activities of the enzyme.
Interestingly, while two conformations appear with equal probability when the docking is performed without the water molecule positioned in the acetylcholine complex, addition of this water molecule results in an extra hydrogen bond with the pyridine nitrogen of nicotine, and stabilizes the conformation presented (Figure 3- Bottom).
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