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Example sentences for: stabilizes

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The C-terminal 30 amino acids of Gα consist of the β6-α5 loop, followed by the α5 helix and finally several amino acids of flexible structure (Figure 1) [ 19 20 21 ] . The β6-α5 loop stabilizes the guanine ring of bound GDP or GTP, and mutations in this region affect guanine-nucleotide binding.
Furthermore, the gain-of-function Smo mutation renders the protein less sensitive to the inhibitors, presumably because the amino-acid substitution directly stabilizes or induces an active conformation.
Examination of the crystal structure of HIV-1 RT reveals the presence of a small groove like region on the floor of the polymerase cleft of p66 [ 11 ] . The β7-β8 loop of p51, comprising of six amino acids denoted as SINNET appears to fit into this groove-like region and likely stabilizes the polymerase domain of p66.
Under in vitro conditions, it has been shown that ibuprofen stabilizes lyszomal membranes, restrains the secretion of lysozomal enzymes from granulocytes, and prevents the aggregation of platelets as well as the immigration of leukocytes [ 1 2 3 4 5 ] .
The two flaps fold over the inhibitor to form a tunnel-shaped active site and are held in this close position by hydrogen bonding from Ile50 and Ile50' NH groups of the enzyme to a water molecule, which in turn is hydrogen bonded to the P2 and P1' CO groups of the inhibitor [ 24 ] . The bonding stabilizes the flaps in a closed position and inhibits the activities of the enzyme.