Example sentences for: stabilized

How can you use “stabilized” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • For some mRNAs, however, initiation of protein synthesis is enhanced or stabilized under the conditions of increased eIF2α phosphorylation.

  • The intensities of GFP fluorescence in nuclei were increased by 48 hours and stabilized after 48 hours in all lines.

  • Recent experiments by Fults and colleagues support the idea that stabilized β-catenin expression in the postnatal CNS is not sufficient to initiate tumor formation [ 36 ] . Using the RCAS-TVA system they showed that overexpression of c-myc, but not of activated β-catenin, promoted the proliferation of neural progenitor cells in vivo and in vitro . In their in vivo experiments expression was initiated in nestin positive cells postnatally via injection of β-catenin stabilized by a point mutation in codon 37.

  • A recent study in Drosophila suggested that Hh stimulates the pathway via Ptc degradation and, as a result, Smo is stabilized through extensive phosphorylation at the plasma membrane where it initiates signaling [ 5 ] . This led to speculation that a Ptc-regulated phosphatase may control the subcellular distribution and stability of Smo [ 5 ] . Although suggestive, the studies in Drosophila did not establish that phosphorylation, translocation or stabilization of Smo is required for pathway stimulation.

  • We first tested Cdc5, because Cdc5 is required for Cdc14 release (Figure 1), and because overexpression of Cdc5 triggers ectopic degradation of Clb2 [ 19 20 ] , which normally depends upon active Cdc14 [ 3 ] . These experiments employed a GAL-CDC5(DB▲) strain, in which expression of Cdc5(DB▲), a stabilized version of Cdc5 lacking the destruction box, was driven by the inducible GAL promoter [ 20 ] . Cells were arrested in G1 by α-factor, supplemented with galactose to induce the GAL promoter, and released into galactose-containing medium.


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