Words similar to sp-a

Example sentences for: sp-a

How can you use “sp-a” in a sentence? Here are some example sentences to help you improve your vocabulary:

4 nM [ 13 ] . When added alone at concentrations of 1-100 nM, rapamycin did not affect SP-A mRNA levels (Fig.
5-10 μM) had no effect on the insulin inhibition of SP-A mRNA while decreasing basal SP-A mRNA levels in a dose-dependent manner when added alone.
The rate of SP-A gene transcription increased in a time-dependent manner (Fig.
Chess and coworkers have shown that transforming growth factor-α and hepatocyte growth factor increase the phosphorylation of p44/p42 MAPK in H441 cells [ 23 ] . Epidermal growth factor, which binds to the same receptor as transforming growth factor-α, increases SP-A content in human fetal lung [ 24 ] . Hepatocyte growth factor has also been shown to upregulate the synthesis of SP-A in rat type II cells [ 25 ] . Thus, phosphorylation of p44/42 MAPK may be involved in the up-regulation of SP-A gene expression, results consistent with our observation that inhibition of basal levels of p44/42 MAPK phosphorylation may decrease SP-A gene expression.
Our studies are suggestive that insulin inhibits SP-A gene transcription via the PI 3-kinase pathway in lung epithelial cells, specifically via the rapamycin-sensitive activation of p70 S6 kinase.