Words similar to sp-a

Example sentences for: sp-a

How can you use “sp-a” in a sentence? Here are some example sentences to help you improve your vocabulary:

In our previous studies, we have shown that insulin inhibits the rate of SP-A gene transcription after a 24-hour exposure [ 7 ] . In this study, we evaluated the effects of insulin on the transcription rate of the human SP-A and α-actin genes at several time-points earlier than those used in our previous studies.
We confirmed these observations by showing that insulin increased the phosphorylation of a specific rapamycin-sensitive residue (threonine 389), present in the linker region of p70 S6 kinase, a phosphorylation event that is known to activate this enzyme [ 22 ] . In contrast, PD98059, an inhibitor of p44/42 MAPK activation, did not block the inhibitory effects of insulin on SP-A gene expression.
Together, our results are suggestive that insulin activates the rapamycin-sensitive PI 3-kinase pathway in lung epithelial cells and that this event leads to an inhibition of SP-A gene transcription.
H441 cells were harvested and total RNA isolated as described previously [ 16 ] . Equal amounts of total RNA from each condition were separated on agarose gels, transferred to Nytran-plus membranes (Schleicher and Schuell, Keene, NH, USA), and subsequently hybridized with a radiolabeled human SP-A cDNA.
The rate of SP-A gene transcription increased in a time-dependent manner (Fig.