Example sentences for: site-specific

How can you use “site-specific” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Site-specific mutations were placed in two regions of Syk.

  • The potential higher-order structural relationship between the APSES and KilA-N domains with the LAGLIDADG site-specific DNA endonucleases and tRNA endonuclease amino-terminal domains has interesting implications for their evolutionary affinities and origin.

  • T1DM susceptibility in the NOD mouse is linked to I-A g7, the murine MHC class II gene that encodes a histidine at position 56 and a serine at position 57 in the β chain, in place of the more frequent proline 56β and aspartic acid 57β [ 3 ] . The development of diabetes is prevented in NOD.PD mice (which are NOD mice with I-A g7) that carry a β chain transgene with site-specific mutations that restore proline and aspartic acid at positions 56β and 57β, respectively [ 4 ] . Furthermore, because of the two amino acid changes in the additional (transgenic) MHC class II allele β chain in NOD.PD mice, NOD.PD mice recognize three additional peptide epitopes in the glutamic acid decarboxylase 65 (GAD65) autoantigen [ 5 ] .

  • The proteolytic cleavage site at amino acid 437 was blocked by the site-specific mutation of amino acid residues 433, 434, and 436 [ 22 ] .

  • 2003) will focus efforts to design novel site-specific inhibitors of the ubiquitin–proteasome pathway.


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