Example sentences for: site-directed

How can you use “site-directed” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To determine individual residues of LcrG required for interaction with LcrV, a systematic site-directed mutagenesis strategy was used to change conserved or charged residues within the delineated interaction region.

  • To ascertain whether MAP kinase directly modulates the receptor function, this amino acid was changed to alanine by site-directed mutagenesis.

  • Mutation of Asn122 to Asp by site-directed mutagenesis destroyed the phosphatase activity, confirming the essential role of this residue of PP1 in catalysis [ 19 ] . PfPP1 was inhibited by NaF, inorganic orthophosphate, and pyrophosphate at respective IC 50 values of 2.5 mM, 10 mM, and 90 μM (data not shown).

  • Methodology for the site-directed mutagenesis of pR is discussed in detail elsewhere (R.

  • To determine which of these potential transcription factor binding sites is responsible for regulating normal CD5 expression, we performed site-directed mutagenesis on the CCAAT (mutC), κE2 (mutK) and Ets (mutE) sites from the StuI B reporter construct.


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