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Example sentences for: shrsp
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However, one change, G1754T in exon 12 was identified that led to a coding change of Gly583Cys in sterolin-1 ( Abcg5 ). This change was found only in rat strains that were confirmed to be sitosterolemic (WKY, SHR and SHRSP), but not in any of the other strains screened (SD, Wistar, WKA, GH or BN).
Interestingly, a similar whole-body accumulation of plant sterols, less severe than in human sitosterolemia, has been reported recently in SHR, SHRSP and WKY rats, but not in the other genetically related rat strains, such as SD, Wistar and WKA rats [ 16 ] . These rats exhibit defects at two levels: increased absorption of sterols (plant and animal) at the intestinal level and decreased excretion of sterols into bile [ 16 ] . The higher sterol absorption in the intestine and the lower biliary excretion of plant sterols in these rat strains led us to hypothesise that Abcg5 or Abcg8 gene mutations may be responsible for the sitosterolemia observed in these hypertensive rats.
This 'mutation' was only detected in SHR, SHRSP and WKY rats and was present in all of these strains as a homozygous change (Table 5).
Studies reported by different investigators have shown that a dietary intake of 10 % canola oil (as part of semi-purified diets) significantly shortened the life-span of SHRSP rats, with accumulation of phytosterols in plasma, red blood cells and tissues [ 15 17 18 19 21 22 ] . Lower red blood cell (RBC) membrane deformability, lower density of platelets, as well as a higher blood pressure were also observed, when compared to a SHRSP group fed with vegetable oils lower in phytosterols (10 % soybean oil vs. 10% canola oil).
Recent linkage mapping studies mapped hypertension QTLs to a number of chromosomal regions in SHR and SHRSP rats [ 35 ] . Our FISH study assigned the STSL locus rat chromosome 6q12, a region where a cluster of blood pressure QTL with Lod score 4~6 has been reported to be present (M6MIT12-M6MIT3, 39 cM distance) in a New Zealand genetically hypertensive rat (GH rat) [ 35 ] . With respect to hypertension, although the SHR and SHRSP strains carry the Gly583Cys mutation, in extensive QTL mapping studies using these strains, no loci mapping to the rat STSL region have been reported [ 35 ] . In our study, the GH rat is neither sitosterolemic, nor has any nucleotide alteration at the STSL locus that would implicate this region as mutated.
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