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Example sentences for: shrsp

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Studies reported by different investigators have shown that a dietary intake of 10 % canola oil (as part of semi-purified diets) significantly shortened the life-span of SHRSP rats, with accumulation of phytosterols in plasma, red blood cells and tissues [ 15 17 18 19 21 22 ] . Lower red blood cell (RBC) membrane deformability, lower density of platelets, as well as a higher blood pressure were also observed, when compared to a SHRSP group fed with vegetable oils lower in phytosterols (10 % soybean oil vs. 10% canola oil).
Abcg8 may have resulted from acquisition of a foreign chromosomal fragment during the Wistar rat strain breeding and established as homozygous change in the WKY, SHR and SHRSP, as well as GH rat strains.
However, one change, G1754T in exon 12 was identified that led to a coding change of Gly583Cys in sterolin-1 ( Abcg5 ). This change was found only in rat strains that were confirmed to be sitosterolemic (WKY, SHR and SHRSP), but not in any of the other strains screened (SD, Wistar, WKA, GH or BN).
Another formal possibility not excluded is that the Gly583Cys missense mutation may have no significance in the accumulation of phytosterols in WKY, SHR and SHRSP, and that the alteration in the 3' UTR or even the intronic changes reported above may be the causative 'mutations'.
Three rat strain, WKY, SHR and SHRSP, that are hypertensive are also sitosterolemic.