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Example sentences for: shrsp
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In comparison, extensive studies on evaluation of high phytosterol diets in SD rats (non-sitosterolemic) have consistently shown to be safe without any adverse consequences [ 36 37 38 39 40 41 42 ] . These intriguing differences between SHRSP and SD rats may now be explained, at least in part, by presence of the Gly583Cys missense mutation in sterolin-1.
The DNA samples from the following rat strains were used: Sprague Dawley (SD, Charles River Laboratories, Wilmington, MA), Wistar (Sea: Wistar, Outbred, SPF, Seac Yoshitomi) and WKA (WKA/Sea, inbred, SPF, Seac Yoshitomi), WKY (WKY/NCrj, inbred, SPF, Charles River Japan, Kanagawa, Japan or Charles River, Wilmington, MA), SHR/Crl (Charles River, Wilmington, MA), SHRSP (SHRSP/Sea, inbred, SPF, Seac Yoshitomi, Fukuoka, Japan), GH and BN.
Recent linkage mapping studies mapped hypertension QTLs to a number of chromosomal regions in SHR and SHRSP rats [ 35 ] . Our FISH study assigned the STSL locus rat chromosome 6q12, a region where a cluster of blood pressure QTL with Lod score 4~6 has been reported to be present (M6MIT12-M6MIT3, 39 cM distance) in a New Zealand genetically hypertensive rat (GH rat) [ 35 ] . With respect to hypertension, although the SHR and SHRSP strains carry the Gly583Cys mutation, in extensive QTL mapping studies using these strains, no loci mapping to the rat STSL region have been reported [ 35 ] . In our study, the GH rat is neither sitosterolemic, nor has any nucleotide alteration at the STSL locus that would implicate this region as mutated.
Three rat strain, WKY, SHR and SHRSP, that are hypertensive are also sitosterolemic.
The SHR strain was derived by selective inbreeding from the Kyoto outbred Wistar colony, and both SHR and SHRSP, as well as WKY strains have been maintained over many generations through brother-sister matings http://rgd.mcw.edu/tools/strains [ 43 44 ] . Healthy WKA and GH rat strains were also generated from outbred Wistar rat strains, but these strains were isolated independently in Japan and New Zealand, respectively (and maintained at other sites as well).
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