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Example sentences for: shrsp
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Recent linkage mapping studies mapped hypertension QTLs to a number of chromosomal regions in SHR and SHRSP rats [ 35 ] . Our FISH study assigned the STSL locus rat chromosome 6q12, a region where a cluster of blood pressure QTL with Lod score 4~6 has been reported to be present (M6MIT12-M6MIT3, 39 cM distance) in a New Zealand genetically hypertensive rat (GH rat) [ 35 ] . With respect to hypertension, although the SHR and SHRSP strains carry the Gly583Cys mutation, in extensive QTL mapping studies using these strains, no loci mapping to the rat STSL region have been reported [ 35 ] . In our study, the GH rat is neither sitosterolemic, nor has any nucleotide alteration at the STSL locus that would implicate this region as mutated.
Thus, this mutation in WKY, SHR and SHRSP lines may not contribute to the hypertension phenotype per se , but may only be responsible for sitosterolemia.
The WKY rat also carries this mutation and a high dietary intake of phytosterols will also increase the blood pressure and decrease the density of platelets, though to a lower extent than that observed in SHRSP rats [ 20 ] . These data support a pathological role of elevated plant sterols in these rats and support the notion that the STSL loci evolved to not only allow for the excretion of cholesterol into bile, but also to keep 'xeno-sterols' from accumulating in the body.
However, one change, G1754T in exon 12 was identified that led to a coding change of Gly583Cys in sterolin-1 ( Abcg5 ). This change was found only in rat strains that were confirmed to be sitosterolemic (WKY, SHR and SHRSP), but not in any of the other strains screened (SD, Wistar, WKA, GH or BN).
Plant sterol metabolism has been extensively evaluated in different rat strains, but the accumulation of plant sterols occurs only in SHR, SHRSP and WKY rats.
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