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Example sentences for: shrsp

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Another formal possibility not excluded is that the Gly583Cys missense mutation may have no significance in the accumulation of phytosterols in WKY, SHR and SHRSP, and that the alteration in the 3' UTR or even the intronic changes reported above may be the causative 'mutations'.
We did not observe any differences between the staining patterns observed for the control rat strains (Wistar or SD) and the mutant hypertensive strains (SHR, SHRSP).
To identify if alterations at the STSL locus could account for these observations, we amplified and directly sequenced Abcg5 and Abcg8 from Wistar, Sprague-Dawley, WKY, WKA, GH, SHR, and SHRSP rats.
Thus, this mutation in WKY, SHR and SHRSP lines may not contribute to the hypertension phenotype per se , but may only be responsible for sitosterolemia.
In comparison, extensive studies on evaluation of high phytosterol diets in SD rats (non-sitosterolemic) have consistently shown to be safe without any adverse consequences [ 36 37 38 39 40 41 42 ] . These intriguing differences between SHRSP and SD rats may now be explained, at least in part, by presence of the Gly583Cys missense mutation in sterolin-1.