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Example sentences for: shrsp

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The GH rat was selected for systolic hypertension that increased with successive generations and maintained through filial matings [ 45 ] . In view of this, the Gly583Cys missense mutation of Abcg5 might result from occurrence of a de novo mutation during breeding at the stage of developing inbred WKY strains and propagated into the SHR and SHRSP lines.
However, one change, G1754T in exon 12 was identified that led to a coding change of Gly583Cys in sterolin-1 ( Abcg5 ). This change was found only in rat strains that were confirmed to be sitosterolemic (WKY, SHR and SHRSP), but not in any of the other strains screened (SD, Wistar, WKA, GH or BN).
We did not observe any differences between the staining patterns observed for the control rat strains (Wistar or SD) and the mutant hypertensive strains (SHR, SHRSP).
In comparison, extensive studies on evaluation of high phytosterol diets in SD rats (non-sitosterolemic) have consistently shown to be safe without any adverse consequences [ 36 37 38 39 40 41 42 ] . These intriguing differences between SHRSP and SD rats may now be explained, at least in part, by presence of the Gly583Cys missense mutation in sterolin-1.
This 'mutation' was only detected in SHR, SHRSP and WKY rats and was present in all of these strains as a homozygous change (Table 5).