Words similar to shr
Example sentences for: shr
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While this manuscript was in review, Scoggan et al also reported identifying Gly583Cys alteration in Abcg5 of SHR, SHRP and WKY rats [ 49 ] .
A number of different groups have reported that genetically hypertensive strains of rats (SHR, SHRSP, WKY) have elevated levels of plasma sitosterol [ 15 16 17 18 19 20 21 22 ] . Although the WKY strain is not considered hypertensive, dietary alterations involving plant sterols appear to increase blood pressure in this strain [ 21 ] . We screened two commercially available hypertensive rats, as well as a 'genetically hypertensive' strain, GH, for plasma plant sterol levels and compared these to two control strains, Sprague-Dawley and Wistar (Table 4).
The GH rat was selected for systolic hypertension that increased with successive generations and maintained through filial matings [ 45 ] . In view of this, the Gly583Cys missense mutation of Abcg5 might result from occurrence of a de novo mutation during breeding at the stage of developing inbred WKY strains and propagated into the SHR and SHRSP lines.
The DNA samples from the following rat strains were used: Sprague Dawley (SD, Charles River Laboratories, Wilmington, MA), Wistar (Sea: Wistar, Outbred, SPF, Seac Yoshitomi) and WKA (WKA/Sea, inbred, SPF, Seac Yoshitomi), WKY (WKY/NCrj, inbred, SPF, Charles River Japan, Kanagawa, Japan or Charles River, Wilmington, MA), SHR/Crl (Charles River, Wilmington, MA), SHRSP (SHRSP/Sea, inbred, SPF, Seac Yoshitomi, Fukuoka, Japan), GH and BN.
have demonstrated that spontaneously hypertensive rats(SHR) with symptoms of heart failure had significantly higher levels ofapoptotic myocytes than control myocytes [ 37 ] .When treated with an angiotensin-converting enzyme inhibitor, thenumber of apoptotic cells in the SHR with symptoms of heart failurewas dramatically reduced to control levels; controls were SHR withoutsymptoms of heart failure [ 37 ] . Kajstura et al.have also reported that angiotensin II increased the percentageof apoptotic cells in isolated adult rat ventricular myocytes, andthis effect was mediated by AT-1 receptors [ 38 ] .Although ventricular function was not assessed in these studies,the observations raise the possibility that, like our findings withcarvedilol, the beneficial effect of ACE-inhibitors or AT-1 receptorblockers in heart failure may in part be attributed to an inhibitionof myocyte apoptosis with a resultant improvement in in vivo cardiacfunction, a concept that needs further study.
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