Words similar to shr
Example sentences for: shr
How can you use “shr” in a sentence? Here are some example sentences to help you improve your vocabulary:
Using GAPDH mRNA expression as a control, expression of Abcg5 and Abcg8 mRNAs appeared to be increased in liver from SHR compared to Sprague Dawley (Fig.
This stimulation is independent of the DNA binding activity of Stat3, since none of the luciferase reporters responsive to SHRs used throughout this report contain the DNA sequence responsive to Stat3 [ 7 ] . We cannot rule out, however, that Stat3 is affecting an independent event that in turn activates SHR transcriptional activity.
have demonstrated that spontaneously hypertensive rats(SHR) with symptoms of heart failure had significantly higher levels ofapoptotic myocytes than control myocytes [ 37 ] .When treated with an angiotensin-converting enzyme inhibitor, thenumber of apoptotic cells in the SHR with symptoms of heart failurewas dramatically reduced to control levels; controls were SHR withoutsymptoms of heart failure [ 37 ] . Kajstura et al.have also reported that angiotensin II increased the percentageof apoptotic cells in isolated adult rat ventricular myocytes, andthis effect was mediated by AT-1 receptors [ 38 ] .Although ventricular function was not assessed in these studies,the observations raise the possibility that, like our findings withcarvedilol, the beneficial effect of ACE-inhibitors or AT-1 receptorblockers in heart failure may in part be attributed to an inhibitionof myocyte apoptosis with a resultant improvement in in vivo cardiacfunction, a concept that needs further study.
Thus, this mutation in WKY, SHR and SHRSP lines may not contribute to the hypertension phenotype per se , but may only be responsible for sitosterolemia.
Our analyses confirmed that WKY, and SHR are sitosterolemic on a chow diet, but neither the control strains, nor the GH rat showed any significant differences.
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