Words similar to shrs
Example sentences for: shrs
How can you use “shrs” in a sentence? Here are some example sentences to help you improve your vocabulary:
Nevertheless, direct protein-protein interaction has been documented by coimmunoprecipitation experiments between Stat3 and AR [ 16 25 ] , GR [ 13 14 ] , PR [ 36 ] , and ER [ 37 ] , suggesting that Stat3 might be involved directly in transcriptional activity elicit by SHRs.
These results can help to elucidate the mechanism by which SHRs in general, and AR in particular, regulate gene expression.
We studied whether Stat3, a transcription factor itself, could act as a coactivator for AR and for other SHRs.
In conclusions, we report here that: 1) a constitutively active form of Stat3 stimulates transcriptional activity of SHRs in a hormone-dependent manner; 2) active Stat3 can act synergistically with other c oactivators to stimulate SHRs transcriptional activity; 3) Stat3 did not affect specificity of AR to other steroid hormones different than androgen, or binding of AR to other HREs; 4) Stat3 increases the sensitivity of AR to androgen.
Having demonstrated that Stat3 enhance AR-mediated gene transcription, we next investigated the role of Stat3 on transcriptional activation with other SHRs.
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