Example sentences for: shrs

How can you use “shrs” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These results can help to elucidate the mechanism by which SHRs in general, and AR in particular, regulate gene expression.

  • These results can add more light to the mechanism by which SHRs, and AR in particular, regulate gene expression.

  • Coactivators are probably present in the nucleus in preassembled multicomplex units ready to associate to activated SHRs.

  • Upon ligand binding, the SHR undergoes conformational changes that involve releas e from the repressor proteins, and translocation to the nucleus where it can bind to specific hormone responsive sequences in the DNA of genes regulated by steroid hormones [ 1 2 ] . The mechanism by which SHRs affect the rate of RNA polymerase II-directed transcription likely involves the interaction of receptors with components of the transcription preinitialization complex.

  • Taken together, Stat3 enhances four different SHRs transcriptional activity in the presence of their corresponding ligand, suggesting that active Stat3 acts as a coactivator for nuclear receptors.


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