Example sentences for: shrs

How can you use “shrs” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We studied whether Stat3, a transcription factor itself, could act as a coactivator for AR and for other SHRs.

  • In conclusions, we report here that: 1) a constitutively active form of Stat3 stimulates transcriptional activity of SHRs in a hormone-dependent manner; 2) active Stat3 can act synergistically with other c oactivators to stimulate SHRs transcriptional activity; 3) Stat3 did not affect specificity of AR to other steroid hormones different than androgen, or binding of AR to other HREs; 4) Stat3 increases the sensitivity of AR to androgen.

  • Regulation of gene transcription mediated by hormone-activated SHRs involves interaction with components of the transcription complex.

  • Coactivators are probably present in the nucleus in preassembled multicomplex units ready to associate to activated SHRs.

  • This stimulation is independent of the DNA binding activity of Stat3, since none of the luciferase reporters responsive to SHRs used throughout this report contain the DNA sequence responsive to Stat3 [ 7 ] . We cannot rule out, however, that Stat3 is affecting an independent event that in turn activates SHR transcriptional activity.


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