Words similar to sic
Example sentences for: sic
How can you use “sic” in a sentence? Here are some example sentences to help you improve your vocabulary:
The cringe-making menu prose--“50 ways to love your liver”--disguises a reasonably echt core of standard deli fair [sic]: cream cheese and lox, salt beef [`corned beef'], gefilte fish--with a few nouvelle intruders like sun-dried tomato and mozarella [sic] salad.
Inactivation of Cdc28 by overexpression of Sic1 suppresses multiple MEN mutants and hyperactivation of Cdc28 by overexpression of Clb2 exacerbates their phenotypes, consistent with the idea that a key function of the MEN proteins is to eradicate Cdc28 activity during the transition from anaphase/telophase to G1 [ 6 7 8 9 ] .
We have previously shown that both net1 tab 2-1and CDC14 TAB 6-1efficiently bypassed the mitotic arrest caused by Tem1-depletion [ 15 18 ] . Furthermore, bypass was accompanied by ectopic Sic1 accumulation and Clb2 degradation.
Sic!
Studies in budding yeast identified SCF Cdc4p, an E3 ubiquitin ligase complex that mediates the ubiquitylation of the CDK inhibitor Sic1p [ 3 4 ] . SCF Cdc4pconsists of at least four proteins: the cullin Cdc53p, the RING domain protein Hrt1p/Rbx1p/Roc1p, the adapter protein Skp1p, and Cdc4p (reviewed in [ 1 ] ). Cdc4p contains two sequence motifs, which are conserved in a wide variety of so-called F-box proteins: C-terminal WD-repeats that are involved in binding the substrate Sic1p in a phosphorylation-dependent manner, and a central F-box [ 5 ] that interacts with Skp1p [ 6 7 ] . Cdc53p in turn binds to Skp1p and Hrt1p/Rbx1p/Roc1p, which bridges Cdc53p with the ubiquitin-conjugating enzyme Cdc34p/Ubc3p [ 6 8 9 10 11 12 ] . In vitro reconstitution demonstrated that SCF Cdc4p, Cdc34p, E1, ubiquitin, and ATP are sufficient to mediate Sic1p polyubiquitylation [ 6 7 ] .
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