Words similar to shp-
Example sentences for: shp-
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Several signaling events, including the activation of Jak kinases 1 and 3 are shared among the 'common γ chain' cytokines [ 50 ] . Other signaling events, such as the activation of Shc, Gab2, SHP-2 and MAPK, are shared among IL-2 and 15, but not the other common γ chain cytokine receptors, and Tyr 388 of IL-2Rβ appears critical for these events [ 51 ] . Despite these signaling similarities, it is clear that the biological properties of IL-2 are unique among the common γ chain cytokines, as the other cytokines cannot compensate for IL-2 in the IL-2 knockout mouse [ 52 ] . In addition, IL-15 appears uniquely critical for the development of NK cells, as evidenced by the phenotypes of IL-15 [ 53 ] and IL-15R α [ 54 ] deficient mice.
However, in murine B lymphoma cells, the CD5 pseudo-ITAM motif mediates its inhibitory action via a SHP-1 independent mechanism [ 24].
In human Jurkat cells and phytohemagglutinin-expanded T lymphoblasts, the CD5 ITIM-like motif is crucial for association with SHP-1, a cytosolic tyrosine phosphotase implicated in the negative regulation of antigen receptor-mediated signaling [ 23].
Further, both the SHP-2/Ras and JAK/STAT3 pathways are activated by IL-6R/gp130 signaling (Fig.
BCR-induced interaction between Cbl and Syk increases the susceptibility of Syk to proteolysis [ 55 ] , possibly through enhancement of ubiquitination [ 56 ] . Expression of a dominant-negative SHP-1 phosphatase in the mature murine B cell line K46 resulted in an increase in BCR-induced Syk kinase activity as measured by C3b phosphorylation in an ICKA and enhanced BCR-induced Ca 2+fluxes [ 57 ] . It remains to be determined if interference with any of these known regulatory proteins is responsible for the dominant-positive effect.
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