Words similar to sgcts

Example sentences for: sgcts

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A unique feature of GCTs is their origin from germ cells at a stage in development where they undergo epigenetic reprogramming [ 6 13 ] . The absence of this epigenetic modification in SGCTs is consistent with their GC-like nature as previously noted [ 6 14 ] . On the other hand, the extensive promoter hypermethylation seen in NSGCTs suggests a mechanistic role in their potential for embryonal and extra-embryonal lineage differentiation [ 6 14 ] . Establishment of DNA methylation in the mammalian genome is controlled by at least three DNA methyltransferases (DNMTs), DNMT1 , DNMT3a and DNMT3b [ 15 ] . The role of these DNMTs in differential de novo methylation in SGCT vs.
2%) SGCTs but in 38 of 63 (60.
Histologically, 29 of these tumors were SGCTs, 44 NSGCTs, and 19 mixed or combined tumors.
Several studies have shown that both NSGCTs and SGCTs exhibit similar genetic alterations, including isochromosome for the short arm of chromosome 12, i(12p) [ 6 ] . Thus epigenetic alterations such as those detected in the current study is one distinct molecular change that distinguishes these two histologic subsets.
To examine the biological role of promoter hypermethylation in GCT, we assessed the levels of gene expression by semi-quantitative RT-PCR in 23 tumors (15 NSGCTs and 8 SGCTs) with known methylation status.