Words similar to sgct

Example sentences for: sgct

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Promoter hypermethylation is common in NSGCT and rare in SGCT
A unique feature of GCTs is their origin from germ cells at a stage in development where they undergo epigenetic reprogramming [ 6 13 ] . The absence of this epigenetic modification in SGCTs is consistent with their GC-like nature as previously noted [ 6 14 ] . On the other hand, the extensive promoter hypermethylation seen in NSGCTs suggests a mechanistic role in their potential for embryonal and extra-embryonal lineage differentiation [ 6 14 ] . Establishment of DNA methylation in the mammalian genome is controlled by at least three DNA methyltransferases (DNMTs), DNMT1 , DNMT3a and DNMT3b [ 15 ] . The role of these DNMTs in differential de novo methylation in SGCT vs.
The rare CpG hypermethylation seen in five SGCT patients may be due to the existence of a minor NSGCT component that might have escaped the histologic diagnosis.
Here we show that hypermethylation is common in NSGCT and rare in SGCT.
We assessed 92 GCT DNAs representing all histologic subsets of NSGCT, and SGCT, and four normal testes for methylation status of CpG islands of 21 gene promoters by methylation-specific PCR (MSP) (Fig.