Words similar to sgcs

Example sentences for: sgcs

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One of these, the HNOB domain, contains the heme-binding site of the SGCs and defines a family of small-molecule binding domains exclusively occurring in animals and bacteria.
2 is present at much higher concentrations within the cell [ 22 23 ] . This ligand specificity of the NO binding domain of animal SGCs is very similar to bacterial cytochrome c' that likewise binds only NO and CO [ 24 ] . The N-terminal region of the α subunit has been shown to bind certain synthetic pyrazolopyridine ligands, which act as potents NO-independent agonists of cyclase activity [ 25 26 ] .
Though both the α and β subunits of SGCs are homologous throughout their entire length, only the β subunit contains the critical heme-binding residue.
Thus, the HNOB and HNOBA domains resemble functionally similar CACHE and CHASE domains, which have also been acquired by certain eukaryotic lineages via lateral transfer from bacteria [ 14 36 37 ] . A phylogenetic analysis of the guanylyl cyclase domains of the animal SGCs shows that their closest relatives are cyclases from various bacteria such cyanobacteria, and Leptospira (data not shown).
Identification of the HNOB and HNOBA domains could help in further investigations of the SGCs that are critical components of the nitric oxide signaling pathway in animals.