Words similar to sgcs

Example sentences for: sgcs

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The histidine is predicted to be positioned next to the N-terminus of an α-helix, and is conserved throughout this superfamily, with the exception of α-subunits of the SGCs (Fig.
Thus, the HNOB and HNOBA domains resemble functionally similar CACHE and CHASE domains, which have also been acquired by certain eukaryotic lineages via lateral transfer from bacteria [ 14 36 37 ] . A phylogenetic analysis of the guanylyl cyclase domains of the animal SGCs shows that their closest relatives are cyclases from various bacteria such cyanobacteria, and Leptospira (data not shown).
2 is present at much higher concentrations within the cell [ 22 23 ] . This ligand specificity of the NO binding domain of animal SGCs is very similar to bacterial cytochrome c' that likewise binds only NO and CO [ 24 ] . The N-terminal region of the α subunit has been shown to bind certain synthetic pyrazolopyridine ligands, which act as potents NO-independent agonists of cyclase activity [ 25 26 ] .
Using sensitive sequence profile analysis we show that the heme-binding domain of the animal SGCs defines a novel family of ligand binding domains that are also widely distributed in bacteria.
However, studies on the SGCs suggest no evidence for a second covalent heme-binding site, implying that this histidine could have some other function.