Words similar to sgc

Example sentences for: sgc

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Interestingly, the solo versions from Nostoc and Anabaena species group strongly with the animal SGC clade, supporting the origin of the latter forms via horizontal transfer from a bacterial source (Rell BP support 80%, 10000 replicates).
In order to probe this domain further we isolated this region from SGC1β (1-185) and seeded a PSI-BLAST search that was run to convergence.
As this long homologous N-terminal extension of SGC subunits does not map to any previously characterized domains, we sought to investigate its provenance through sequence analysis methods.
Interestingly, binding studies on a synthetic pyrazolopyridine SGC agonist, BAY 41-2272 have suggested a role for the region 236-290 of the human SGC1 α-subunit in interacting with this ligand [ 25 26 ] . Though actual cross-linking occurred with cysteine residues situated just N-terminal to the HNOBA domain, it is likely that the rest of domain is involved in contact with the ligand.
PSI-BLAST searches initiated with the C-terminal part of the SGC-specific extension (the region in between the above-detected N-terminal-most domain, and the C-terminal cyclase domain; human SGC1β, region: 200-370) recovered homologous regions from all other animal soluble guanylyl cyclases, and, additionally, N-terminal regions of histidine kinases from Nostoc and Anabaena species (eg.