Words similar to sgc

Example sentences for: sgc

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Studies on the human SGC1 suggest that the synthetic pyrazolopyridine ligand binds at site distinct from NO and heme, but requires the heme-binding site for its action [ 25 26 ] . This could imply a synergy or cooperation between these domains in heme interation and cyclase activation.
PSI-BLAST searches initiated with the C-terminal part of the SGC-specific extension (the region in between the above-detected N-terminal-most domain, and the C-terminal cyclase domain; human SGC1β, region: 200-370) recovered homologous regions from all other animal soluble guanylyl cyclases, and, additionally, N-terminal regions of histidine kinases from Nostoc and Anabaena species (eg.
The N-terminal region of the β subunit forms a covalent link with heme via a histidine (H105 in human SGC1β) [ 21 ] . Though the porphyrin is identical to that found in hemoglobin, it only binds NO and carbon monoxide, and not oxygen, even though O
Those versions that lack the heme-binding histidine might either non-covalently interact with heme, as in the case of the SGC α-subunits, or bind some other unknown ligand.
Interestingly, binding studies on a synthetic pyrazolopyridine SGC agonist, BAY 41-2272 have suggested a role for the region 236-290 of the human SGC1 α-subunit in interacting with this ligand [ 25 26 ] . Though actual cross-linking occurred with cysteine residues situated just N-terminal to the HNOBA domain, it is likely that the rest of domain is involved in contact with the ligand.