Words similar to sgc
Example sentences for: sgc
How can you use “sgc” in a sentence? Here are some example sentences to help you improve your vocabulary:
As this long homologous N-terminal extension of SGC subunits does not map to any previously characterized domains, we sought to investigate its provenance through sequence analysis methods.
A PSI-BLAST search was initiated with the conserved N-terminal extension of the SGC (human SGC1β, gi: 4504215, region 1-360), using an inclusion threshold of .01, and compositional bias based statistics to eliminate false positives arising due to peculiarities of sequence composition.
Those versions that lack the heme-binding histidine might either non-covalently interact with heme, as in the case of the SGC α-subunits, or bind some other unknown ligand.
Studies on the human SGC1 suggest that the synthetic pyrazolopyridine ligand binds at site distinct from NO and heme, but requires the heme-binding site for its action [ 25 26 ] . This could imply a synergy or cooperation between these domains in heme interation and cyclase activation.
In order to probe this domain further we isolated this region from SGC1β (1-185) and seeded a PSI-BLAST search that was run to convergence.