Words similar to rpn

Example sentences for: rpn

How can you use “rpn” in a sentence? Here are some example sentences to help you improve your vocabulary:

Detection antibodies (all from Dako; 1:5,000 for 1 h at room temperature) were mouse-anti-goat Ig, mouse-anti-rat Ig, rabbit-anti-mouse Ig, and porcine-anti-rabbit Ig-HRP [ 66 ] . To visualize all transferred proteins, we used the ECL protein biotinylation labeling modules (RPN 2202, Amersham) and streptavidin alkaline phosphatase (V020402, Amersham) in accordance with the manufacturer's instructions.
Csn5p contains a motif closely resembling the conserved cysteine box previously recognized in the catalytic center of deubiquitylating enzymes and in the budding yeast proteasome subunit Rpn11p [ 23].
Identifying Rpn11 and Csn5 as members of a novel class of metallohydrolases immediately elevates them into promising “drugable” candidates.
Notably, Rpn11 shares close homology with Csn5, which is also responsible for proteolytic activities in its respective complex.
While Csn5 is thought to impede the action of ubiquitin ligases through shaving cullins from their Rub1/Nedd8 modification (and possibly also by deubiquitinating substrates bound to the cullins), the outcome of Rpn11 inhibition will depend largely on whether Rpn11 participates primarily in shaving substrates from their chains, promoting release and rescue, or in trimming the polyubiquitin tag, allowing for proteolysis quality control (Figure 2).