Example sentences for: rpn

How can you use “rpn” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Csn5p contains a motif closely resembling the conserved cysteine box previously recognized in the catalytic center of deubiquitylating enzymes and in the budding yeast proteasome subunit Rpn11p [ 23].

  • Detection antibodies (all from Dako; 1:5,000 for 1 h at room temperature) were mouse-anti-goat Ig, mouse-anti-rat Ig, rabbit-anti-mouse Ig, and porcine-anti-rabbit Ig-HRP [ 66 ] . To visualize all transferred proteins, we used the ECL protein biotinylation labeling modules (RPN 2202, Amersham) and streptavidin alkaline phosphatase (V020402, Amersham) in accordance with the manufacturer's instructions.

  • Deubiquitinases, such as Rpn11, serve as proofreading devices for reversal of fortune at various stages of the process, right up to the final step before irreversible degradation by the proteasome.

  • Notably, Rpn11 shares close homology with Csn5, which is also responsible for proteolytic activities in its respective complex.

  • This metalloprotease-like activity maps to the putative catalytic MPN+/JAMM motif of the lid subunit Rpn11 and lies at the heart of proteasome mechanism by linking deubiquitination with protein degradation.


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