Words similar to retinoic
Example sentences for: retinoic
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The HL-60 human promyelocytic leukemia cell line responds in culture to sub-micromolar concentrations of retinoic acid ( all-trans and 13-cis ) by undergoing terminal differentiation to a granulocytic cell with the ability to phagocytose and reduce nitroblue tetrazolium [ 28 ] . The response to retinoic acid in HL-60 cells is dependent on the expression of the retinoic acid receptor RAR α [ 29 ] . The use of all-trans retinoic acid in differentiation therapy for patients with acute promyelocytic leukemia has resulted in prolonged, complete remissions when combined with cytotoxic chemotherapy, and may provide complete, long-term remissions as a single agent [ 30 ] .
[ 8 ] characterized gene expression for retinoic acid receptors (RAR) α, β and γ as well as retinal binding proteins (RBP) during early porcine conceptus development and trophoblast elongation.
Stage 3 medium was supplemented with 2 μM all- trans retinoic acid (RA) (Sigma) and had a final glucose concentration of either 5 or 17 mM.
In addition, our results indicate that in HL60 cells, the prototype cell line for studying retinoic acid induced cell differentiation, ALDH1A1 is not the operative oxidizing enzyme for retinal.
In vivo studies have supported the conclusion that CBP/p300 are components of the hormonal-regulation of transcription in fibroblasts isolated from a p300-/- mouse; and loss of the p300 gene severely affects retinoic acid (RA)-dependent transcription [ 91 ] . In a separate study using hammerhead ribozymes that specifically cleave CBP or p300 mRNA, Kawasaki et al [ 92 ] reported that reduced cellular CBP or p300 levels resulted in compromised expression of endogenous RA-inducible genes such as p21/Waf1 and p27 cdk inhibitors.
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