Words similar to retinoid
Example sentences for: retinoid
How can you use “retinoid” in a sentence? Here are some example sentences to help you improve your vocabulary:
Therefore while ligand bound RARα has been shown to activate a large number of RA target genes, the hypophosphorylated form of the receptor created in some cells following retinoid treatment may be important in transcriptional repression.
Several retinoid and non-retinoid ligands have been described, which activate one or a combination of RAR isoforms.
However, the rats were vitamin A-deficient, and it is not known whether the same effects would be seen in vitamin A-replete animals, such as were used in the present study, or whether the response would vary with the specific retinoid used.
Peroxisome proliferator-activated receptors (PPARs) belong to a group of nuclear receptors that include steroid, retinoid, thyroid hormone receptors and others [ 21 22 23 ] . There are three types of PPARs: PPARα is expressed predominantly in the liver, heart, kidney, brown adipose and stomach mucosa, and is important for lipid catabolism.
Until recently, LC-PUFA effects on gene transcription were thought primarily to be mediated by a single subfamily of orphan nuclear receptors - peroxisome proliferator activated receptors (PPARs); however, it is now becoming evident that FAs can affect many different genes either via direct interactions or indirectly through additional transcription factors including hepatic nuclear-4α (HNF-4α), nuclear factor κβ (NF-κβ), retinoid X receptor α (RXRα), sterol regulatory element binding protein-1c (SREBP-1c), and liver X receptors (LXRα and LXRβ) [ 17 ] . Indeed, the enthusiasm for uncovering the biological pathways underlying the beneficial actions of LC-PUFA has revealed a story that is increasingly more complex than originally supposed [ 23 ] , thereby making microarray technology an ideal platform to further decipher the many roles of these nutritional lipids.
Loading...