Words similar to retinoid
Example sentences for: retinoid
How can you use “retinoid” in a sentence? Here are some example sentences to help you improve your vocabulary:
[ 7 ] This system is comprised of a chimeric protein composed of the VP16 activation domain (Vg) fused to an ecdysone receptor (EcR) with altered DNA-binding specificity heterodimerizes with the retinoid X receptor (RXR) and binds a unique synthetic response element not recognized by natural nuclear hormone receptors.
Until recently, LC-PUFA effects on gene transcription were thought primarily to be mediated by a single subfamily of orphan nuclear receptors - peroxisome proliferator activated receptors (PPARs); however, it is now becoming evident that FAs can affect many different genes either via direct interactions or indirectly through additional transcription factors including hepatic nuclear-4α (HNF-4α), nuclear factor κβ (NF-κβ), retinoid X receptor α (RXRα), sterol regulatory element binding protein-1c (SREBP-1c), and liver X receptors (LXRα and LXRβ) [ 17 ] . Indeed, the enthusiasm for uncovering the biological pathways underlying the beneficial actions of LC-PUFA has revealed a story that is increasingly more complex than originally supposed [ 23 ] , thereby making microarray technology an ideal platform to further decipher the many roles of these nutritional lipids.
Therefore while ligand bound RARα has been shown to activate a large number of RA target genes, the hypophosphorylated form of the receptor created in some cells following retinoid treatment may be important in transcriptional repression.
Peroxisome proliferator-activated receptors (PPARs) belong to a group of nuclear receptors which includes steroid, retinoid, thyroid hormone receptors and others [ 19 20 21 ] . There are three types of PPARs: PPARα is found predominantly in the liver, heart, kidney, brown adipose and stomach mucosa, and is important for lipid catabolism.
A systematic examination of the effects of RXR ligands and retinoid status on a number of the growing set of CAR target genes will be required to explore this possibility.
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