Words similar to retinoids
Example sentences for: retinoids
How can you use “retinoids” in a sentence? Here are some example sentences to help you improve your vocabulary:
Provocative mechanistic connections have been made between the steroid hormone superfamily, including the SERMS and retinoids, and the TGF-β family of multifunctional growth factors.
Retinoids can also affect cellular responsiveness to TGF-βs at the level of receptor expression and downstream events [ 37, 38].
Reversible change of endothelial cell shape, mutual orientation of cells in certain directions, changes in intercellular contacts, are controlled by a number of factors, such as, cooperative stimulation of the receptors or the systems of second messengers [ 32, 33], dietary ingredients, e.g., retinoids [ 34], exercise [ 35, 36], and fluid-imposed shear stress [ 37, 38, 39].
Androgen exerts its biologic effects by binding to and activation of androgen receptor (AR) that trans-activates target genes through androgen responsive element (ARE) in the promoter of target genes [ 15 ] . In human breast cancer cells the effectiveness of retinoids in cell growth suppression was dictated by the presence of RAR [ 16 ] . Estrogen regulation of the expression of RAR α was mediated by interactions between estrogen receptor (ER) and estrogen responsive element (ERE) in the promoter of RAR α gene [ 17 ] . Because the DNA binding domains of steroid receptors including AR and ER are highly homologous, we postulated that similar mechanisms might also mediate the effect of androgen on RAR genes in prostate cells.
In the present study, we used a carcinogen-induced rat model of mammary carcinogenesis to test whether chemoprevention by tamoxifen and by two different retinoids (4-HPR, also known as fenretinide; and 9-cRA) is associated with local upregulation of TGF-βs in the initiated mammary gland.
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