Example sentences for: retinoids

How can you use “retinoids” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In conclusion, we have shown that treatment of rats with tamoxifen or retinoids results in effective chemoprevention of mammary tumorigenesis, without any detectable effect on local expression of TGF-βs.

  • Tamoxifen, alone or in combination with retinoids, decreased tumor incidence by more than 70% by the end of the study, whereas 9cRA alone decreased it by 50%.

  • Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are nuclear transcription factors that mediate the action of retinoids [ 11 12 ] . We have demonstrated that in the rat, castration resulted in an increase in mRNAs for RAR α and γ in the prostate; such effects were prevented by T replacement [ 13 ] . We also demonstrated that the levels of mRNAs for RAR α and γ in non-tumorigenic rat epithelial cells (NRP152) were down-regulated, whereas those in tumorigenic cells (NRP154) were unaffected or up-regulated following T treatment [ 14 ] . In addition, RAR α was over-expressed in tumorigenic NRP154 cells.

  • Retinoids, a family of compounds structurally related to vitamin A, have already shown potential in this regard [ 2, 3, 4, 5, 6, 7].

  • We saw a lesser effect with 4-HPR, although this type of phenomenon has also been described in the literature for retinoids [ 4].


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