Words similar to retinoblastoma
Example sentences for: retinoblastoma
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These observations showed that a component(s) secreted by retinoblastoma cells enhanced the PEDF-receptor interactions.
, transduction by retrovirus and selection for drug resistance) produces immortal cell lines with limited transformation phenotypes [ 4 5 ] . However, expression of Tag has profound effects on the cell cycle, significantly reducing cell doubling time and increasing saturation density [ 4 5 6 ] . These direct effects of Tag result from binding and inactivation of the retinoblastoma family proteins (p130, Rb, p107) and the tumor suppressor, p53 [ 7 8 9 ] . Tag is rate limiting for G 1 transit, and this effect (as well as saturation density and growth in soft agar) is Tag-dose dependent [ 3 10 11 12 ] . Since the cell lines in this study are capable of entering a quiescent state at saturation density [ 6 ] , one might expect that the levels of Tag would decrease at saturation and as cells progressively slow down as a function of cell density.
It induces neuronal differentiation in retinoblastoma cells, protects retina neurons (including photoreceptors) from death by apoptosis and other insults, and has a morphogenetic effect on photoreceptor cells [ 3 4 5 6 ] . It also has neurotrophic effects on neurons from the cerebellum, hippocampus and spinal cord [ 7 8 9 10 11 12 ] . In the intact retina, this factor is identified as a secreted protein associated by ionic interactions with the interphotoreceptor matrix [ 13 14 ] , where GAGs are the major polyanionic components.
Human retinoblastoma Y-79 cells (0.
Cortical astrocytes were harvested from neonatal C57BL/6 mice and infected with a replication-defective retrovirus encoding Tag and neomycin resistance as previously described [ 13 ] . The transferred viruses were SV40-6 [ 5 ] , in which wild type Tag is expressed from the M-MuLV LTR promoter; SV(X)T K1, which is constructed the same as SV40-6 except that the Tag is mutant [ 38 ] and defective for binding the retinoblastoma protein family [ 39 ] ; Linker-tkT, in which the cDNA for Tag is expressed from the herpes simplex 1 tk promoter [ 11 ] . The differentiation and transformation phenotypes of the cell lines utilizing the M-MuLV LTR promoter have been described [ 6 13 ] . The Linker-tkT lines (tkT) were either isolated as clones after G418 selection (as previously described) [ 6 ] or frozen immediately after selection (pooled clones) and clonally selected at a later time.
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