Words similar to retinitis
Example sentences for: retinitis
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CMV is the most important pathogen among these patients and the virus can cause both direct and indirect effects [ 8 9 10 11 12 13 ] . Among solid organ transplant recipients, the effects of CMV disease are similar among all patients, with the exception being the effect on the transplanted organ [ 10 14 15 16 17 ] . The most common disease presentation of CMV in AIDS patients is retinitis [ 8 11 ] . The significance of CMV disease in transplant and HIV infected individuals goes much further than the direct pathological effects because CMV has been shown to be an immune modulator and may contribute significantly to the net immunosuppressive status of the patient [ 11 ] . This immunomodulation would therefore increase the susceptibility to superinfections from other pathogens.
Lower copy numbers of this mutation (~ 70%) are associated with neuropathy, ataxia and retinitis pigmentosa (NARP) whereas high copy numbers (>90%) give rise to Leigh syndrome [ 15].
Four are implicated in retina pathology: GNAT1 and ARR (night blindness), RHO (retinitis pigmentosa), and GUCA1A (cone dystrophy).
Neurogenic weakness, ataxia, and retinitis pigmentosa (NARP)
It has been reported before that an increased excretion of orotate in sick children may not be uncommon and that a positive allopurinol load test may indicate unrecognized mitochondrial disease, making orotic acid as a potential marker of mitochondrial dysfunction [ 35 ] . A potential link between mitochondrial cytopathies and urea cycle dysfunction has also been suggested by the findings of hypocitrullinemia in patients with neurogenic weakness, ataxia and retinitis pigmentosa (NARP) syndrome (Mendelian Inheritance in Man database *551500) caused by a T8993G mutation in mtDNA that triggers ATPase deficiency [ 36 37 ] . It was hypothesized that the NARP mutation would cause complex V deficiency in the small intestine as well, thus reducing the availability of mitochondrial ATP required for citrulline synthesis.
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