Words similar to regulated
Example sentences for: regulated
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Tyrosine phosphorylation of the substrate domain leads to the recruitment of other downstream adaptors such as crk and nck, as well as other downstream effectors possessing SH2 domains, and signaling events attributed to this domain include activation of the JNK MAPK pathway and control of adhesion and migration of cells [ 6 10 16 38 44 ] . We constructed a chimera between a kinase that phosphorylates Cas in vivo and the substrate domain of Cas, in order to determine events regulated by this domain.
[ 11 ] . Similar patterns of regulation of specific transcripts were observed and several examples of the differentially regulated genes are indicated in Figure 4. Qualitatively similar results using a direct RNA-dye coupling procedure can be achieved using the Micromax™ ASAP RNA Labeling Kit (Perkin Elmer Life Sciences, Inc. cat.
Expression of apoptosis-related molecules, such as Bcl-xS, Bax, and caspase-3, seems to be little regulated in the early stage of this vessel remodeling process.
The residues in the MIDAS motifs lie on three closely apposed loops located on the upper edge of the β-sheet, where they form the metal-binding site, with oxygen atoms in the aspartate, serine and threonine residues coordinating the metal ion [ 9 ] . In integrin α2β1, which is a collagen receptor, the metal-binding site also binds the collagen ligand through the conserved glutamate in a GFOGER motif (O = hydroxyproline) completing the coordination sphere of the metal [ 28 ] . In vivo, the binding of collagen at this site appears to be regulated through a conformational shift in which the loops forming the MIDAS site change from a closed to an open conformation [ 29 30 31 ] . Other proteins containing a domain with all three MIDAS motifs include the D-subunit of magnesium chelatase [ 32 ] , Ca-activated chloride-channel protein [ 33 34 ] , nitrate reductase (accession AAC79447), and the D subunit of nitric oxide reductase (accession AAC45374).
Analysis revealed a relatively high false positive error rate in the naïve versus axotomy (experimental) comparisons (16%) when using only a 2-fold criterion for regulated gene detection.
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