Words similar to reactivated
Example sentences for: reactivated
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Demethylation of the promoters reactivated the gene expression in MGMT , RARB and RASSF1A genes.
They usually produce inaparent infection or transient immune compromise in otherwise healthy hosts but are able to cause life-threatening primary or reactivated infections in individuals with congenital or acquired T-cell immunodeficiencies [ 7 8 9 10 11 12 13 14 15 ] . The spectrum of diseases caused by lymphotropic herpesviruses is well documented in patients undergoing bone marrow transplantation (BMT) [ 8 9 10 11 ] or organ transplantation [ 12 13 ] and in individuals infected with human immunodeficiency virus (HIV) [ 14 15 ] . In patients undergoing conventional anticancer therapy without BMT, the data focusing on EBV, CMV or HHV-6 infection are scarcely documented and mostly reported as individual cases [ 16 17 18 19 ] . With combined diagnostic approach of serology and viral DNA detection we performed a prospective study of children undergoing non-BMT therapy for cancer to demostrate the incidence of LH infections.
In addition, a number of genes that showed no evidence of full-length CpG methylation was also reactivated upon azacytidine treatment.
Latent CMV in many organs can be reactivated from its dormant state by several means of immunosuppression, including transmission from donors to immunosuppressed recipients of transplants, and blood transfusion.
CMV, a herpes virus, causes chronic asymptomatic infections in immunocompetent individuals, termed latency [ 13 ] . However, in situations of immunocompromise, CMV is reactivated, which in many cases leads to organ failure and death [ 13 ] . Epidemiological reports indicate that chronic CMV infections in humans may play an important role in pathogenesis of vascular diseases such as atherosclerosis [ 14 ] and systemic sclerosis [ 11 12 ] . In addition, a recent report [ 15 ] revealed that SSc autoantibodies bind to CMV late protein UL94 and induce apoptosis in endothelial cells therefore implicating molecular mimicry as a potential mechanism accounting for the link between SSc and CMV.
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