Words similar to rdrps

Example sentences for: rdrps

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An alternative scenario holds that the RDRPs are ancient enzymes that diverged from the evolutionary precursor of DDRP at a very early, pre-LUCA stage of evolution, albeit after the duplication that led to the differentiation of the β and β' versions of the DPBB domain.
One class of substrates of the extant eukaryotic RDRPs are small RNAs, such as microRNAs and stRNAs [ 84 85 86 87 88 89 90 ] , and analogous small RNAs have been identified in bacteria [ 91 92 93 94 ] . Given that small RNAs are likely to have been abundant in the hypothetical ancient RNA world, RDRPs might have been involved in the replication of such RNAs since an early stage of evolution.
These searches, e.g. the search initiated with the core RDRP module from Petunia (residues 37-775), readily retrieved RDRPs from plants, C. elegans , Dictyostelium discoideum , several fungi, and Giardia lamblia with statistically highly significant expectation (E) values.
To investigate the distribution of this motif in the entire protein database, we conducted pattern searches using the GREF program of the SEALS package, with queries corresponding to the residue conservation profile in the predicted active sites of the RDRPs.
Among nucleic acid polymerases, a DxDxD motif is conserved only in the RDRPs, the DDRP β' subunits and the euryarchaea-specific DNA polymerase subunit II.