Words similar to rdrp
Example sentences for: rdrp
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As components of the functional viral RdRP, N and P bind each other [ 23 ] . It was, therefore, important to ask whether they need each other (or other viral proteins) in order to interact with profilin, or whether they are individually capable of binding profilin.
The RDRP is present in one or more copies in a wide range of eukaryotes, from early-branching parabasalids, such as Giardia , to multicellular forms, including fungi, plants and animals [ 57 58 ] . This broad representation in eukaryotes, including organisms that are considered primitive, suggests that RDRP might have been encoded in the genome of the common ancestor of all modern eukaryotes.
Together these proteins transcribe the genomic RNA wrapped with nucleocapsid protein N. It is only the N-RNA complex, and not the naked RNA, that serves as the functional template for the viral RdRP.
Moreover, the functional viral RdRP, as detailed later for RSV, is a complex holoenzyme composed of viral as well as cellular proteins [ 17 18 19 20 21 22 23 ] . Second, many NNR viral genomes and proteins are currently expressed from vaccinia-based cDNA clones, which generally requires superinfection by vaccinia virus [ 22 23 ] . Unfortunately, vaccinia virus itself is a major modulator of cellular signaling, including MAP kinase pathways and the actin cytoskeleton [ 24 25 26 ] . It is, therefore, virtually impossible to study the interaction between cellular signaling pathways and NNR viruses in cells that are also superinfected by vaccinia virus [ 24 25 26 ] . Third, mutations in the recombinant DNA are "permanent", and thus, the mutational phenotype cannot be switched on at pre-determined time points in infection.
Taken together, all these observations point to a scenario for the origin of the RDRP, under which the RDRPs and the YRHs diverged from the DDRPs at a stage of evolution that succeeded the divergence of the DPBB domains of the β and β' subunits (Fig.
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