Example sentences for: rar-α

How can you use “rar-α” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We first built a model of the RAR-α agonist binding pocket from the crystal structure of the RAR-γ ligand binding domain (RAR-γ LBD) / all-trans RA complex [ 18].

  • However, in the complex with RAR-α, this ketone oxygen shares an hydrogen atom with the hydroxyl group of serine 234, and forms a stabilizing hydrogen bond, while a steric clash occurs in the other two RAR isoforms, where residue 234 is an alanine.

  • 1c), while RAR-γ was only 12% active and RAR-α not active at all under the same conditions (Fig.

  • Moreover, stage 2 NS-derived cells expressed RA receptors including RAR-α and RAR-γ (see Figure 1C), indicating competence for RA signals.

  • Consequently, our model provides a rational for Am580 isoform specificity, suggesting that it is relevant and could be used as a template for the discovery of novel RAR-α agonist structures.


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