Words similar to rar
Example sentences for: rar
How can you use “rar” in a sentence? Here are some example sentences to help you improve your vocabulary:
Repression of RA responsive gene expression was believed due to the inability of this RAR to interact with CBP via its shortened carboxyl terminus [ 5 ] . By the same token this mutant receptor did not affect RA inhibition of AP-1 activity, presumably due to its inability to compete for CBP [ 11 ] . We observed decreased AP-1 activity in transient transfections using the RAR403 mutant likely due to decreased EGFR expression.
RAR, retinoic acid receptor
It will be interesting to test these molecules for anti-proliferative activity, both in vitro and in vivo . The observation that agonist 1 does not belong to any of the series of RAR ligands described so far makes this compound particularly interesting for further development.
Androgen exerts its biologic effects by binding to and activation of androgen receptor (AR) that trans-activates target genes through androgen responsive element (ARE) in the promoter of target genes [ 15 ] . In human breast cancer cells the effectiveness of retinoids in cell growth suppression was dictated by the presence of RAR [ 16 ] . Estrogen regulation of the expression of RAR α was mediated by interactions between estrogen receptor (ER) and estrogen responsive element (ERE) in the promoter of RAR α gene [ 17 ] . Because the DNA binding domains of steroid receptors including AR and ER are highly homologous, we postulated that similar mechanisms might also mediate the effect of androgen on RAR genes in prostate cells.
Treatment of LNCaP cells with T alone for 6 h resulted in dose-dependent, biphasic increases in levels of RAR α and γ mRNA transcripts, with the maximal effect of 2-20 nM (P < 0.05; Figure 2).
Loading...