Words similar to rar

Example sentences for: rar

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The effects of the vitamin A metabolite retinoic acid (RA) are mediated by two classes of ligand dependent transcription factors, the retinoic acid receptors (RAR) and the retinoid X receptors (RXR) [ 1 ] . The RARs are activated by all trans RA and 9-cis RA whereas the RXRs are activated by 9-cis RA only.
Here, we describe the effect of coactivator proteins SRC-1 (Acc# AJ000882, U90661, Table 1) and p300 (Acc# U01877, Table 3), and their relation to differentiation genes such as retinoic acid receptor (RAR/PML, Acc#: X06614, Table 1), and Leptin receptor variant (Acc#: U66496, Table 1); all of which are down-regulated in Tat expressing cells (Figure 5).
For reasons not yet clear, both agonists and antagonists of RAR can present anti-tumor activity against breast, prostate, lung cancer or leukemia [ 1, 2, 3, 4, 5, 6, 7].
Our approach enabled the discovery ab initio of RAR agonists displaying some activity at 50 nM with a 7% success rate.
An RARα clone truncated after amino acid 403 was effective in repressing reporter gene activity and blocking wild type RAR function [ 10 11 ] . A single amino acid change in RARα (G303E) impaired RA binding affinity and significantly reduced reporter gene activity from responsive promoters.