Words similar to rar

Example sentences for: rar

How can you use “rar” in a sentence? Here are some example sentences to help you improve your vocabulary:

The family of retinoic acid receptors includes those that bind only all-trans retinoic acid (RAR α,β,γ and those that bind either all-trans retinoic acid or 9-cis retinoic acid (RXR α,β,γ Since the transcriptional regulation of the retinoic acid ligand/receptor complex appears to involve the binding of receptor heterodimers (RAR/RXR), the specific cellular response may depend on the ratio of all-trans to 9-cis retinoic acid formed, as well as the expression of receptor subtypes.
Repression of RA responsive gene expression was believed due to the inability of this RAR to interact with CBP via its shortened carboxyl terminus [ 5 ] . By the same token this mutant receptor did not affect RA inhibition of AP-1 activity, presumably due to its inability to compete for CBP [ 11 ] . We observed decreased AP-1 activity in transient transfections using the RAR403 mutant likely due to decreased EGFR expression.
RAR/RXR binding to nuclear receptor corepressors such as NCoR and SMRT in the absence of ligand inhibits activation of RA responsive genes [ 3 4 ] . Ligand binding displaces the repressors and recruits coactivator proteins such as CBP which have histone acetyltransferase activity [ 5 ] . Histone acetylation allows for chromatin unwinding and transcriptional initiation of target gene expression [ 6 ] .
A similar mechanism may also pertain for the effects of T on RAR γ since the DNA binding domains are highly homologous among RARs.
RAR α and γ mRNA