Example sentences for: promotes

How can you use “promotes” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • recently demonstrated that partially purified CSN promotes the cleavage of Pcu1p-Ned8p conjugates in vitro [ 10], but it remained unclear whether the enzymatic activity is contained within one of the CSN subunits or a tightly associated peptidase.

  • The release of Cdc14 from nucleolar Net1 promotes mitotic exit [ 15 17 18 ] . net1 tab 2-1cells display a panel of nucleolar defects including reduction of nucleolar silencing, mislocalization of nucleolar antigens, alteration of rDNA morphology, and reduction of rRNA synthesis [ 16 18 ] . To test whether perturbation of nucleolar structure is consistently associated with bypass of cdc15Δ, we immunolocalized the nucleolar antigen Nop1 in all tab mutants.

  • Evidence has been accumulated that TGFβ promotes late-stage tumorigenesis by stimulating angiogenesis and invasive behaviour of tumor cells, enhancing immunosuppression and supporting epithelial-mesenchymal transition of cancer cells [ 4 ] . Furthermore, TGFβ is believed to be part of a vicious circle in bone metastases as it gets released from osteoclast-degraded bone substance and subsequently stimulates PTHrP gene expression in nearby metastatic cancer cells which in turn leads to an activation of osteoclastic bone resorption [ 11 ] . Therefore, it is of great interest to understand in more detail the molecular aspects of TGFβ-mediated gene expression in metastatic breast cancer cells and to explore ways to interfere with this tumorigenic signalling.

  • These include, PDCD6 , a protein that plays a role in T cell receptor-, FAS-, and glucocorticoid-induced cell death [ 11 ] ; TERT , a gene that encodes a reverse transcriptase component of telomerase, dysfunction of which promotes chromosomal instability [ 12 ] ; and TRIP13 , a thyroid hormone receptor interacting protein that binds with the human papillomavirus type 16 (HPV16) E1 protein [ 13 ] . We have identified POLS gene that encodes a DNA polymerase sigma, and plays a role in DNA replication and sister chromatid cohesion at the proximal minimal deleted region [ 14 ] . We performed a semi-quantitative RT-PCR analysis of all four genes ( PDCD6 , TERT , TRIP13 , and POLS ) in eight CC cell lines and did not find evidence for lack of or down regulated expression compared to normal cervix (Fig.

  • The recE gene product of the Rac prophage converts dsDNA ends into 3' protruding single-stranded form and the recT gene product promotes recombination by annealing them with a homologous DNA in its vicinity (for review, see [ 7 8 ] ). This recombination may result in one progeny DNA (non-conservative recombination) or two progeny DNAs (conservative double-strand break repair) [ 9 ] . In a recBC sbcBC background, a ds end stimulates homologous recombination that results in only one progeny DNA (non-conservative recombination) [ 10 ] . Analysis of the stimulation of recombination by replication (for review, see [ 11 ] ) and analysis of altered chromosomal replication (for review, see [ 12 ] ) led to the proposal that a chromosomal ds break formed during replication fork arrest triggers homologous recombination, which would reconstitute a replication fork (for review, see [ 5 ] ).


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