Words similar to promoter
Example sentences for: promoter
How can you use “promoter” in a sentence? Here are some example sentences to help you improve your vocabulary:
At a slightly lower cutoff of 0.06, additional genes involved in respiration and utilization of alternative carbon sources were assigned to the cluster, making the enrichment of the promoter element recognized by the catabolite repressor Mig1p statistically significant [ 40, 41, 42].
To further examine the role of promoter methylation in gene inactivation, we treated five NSGCT cell lines (2102E-R, 833K-E, Tera-1, Tera-2, and 218A) with 5-Aza-2' deoxycytidine and analyzed the expression of MGMT , RASSF1A , RARB , and BRCA1 genes.
The library of polymerase variants was cloned behind the T3-like promoter and three rounds of selection and amplification (as described in Figure 1) were carried out.
This probably reflects the difference in sensitivity to CPT between exogenous and endogenous promoters due to the protective role of chromatin surrounding the endogenous promoter.
3 region to which RASSF1A maps undergoes deletions in many solid tumor types, including GCTs [ 9 ] . RASSF1A encodes a splice variant of human RAS effector homologue, which interacts with the XPA protein and functions as a negative regulator of cell growth [ 16 17 ] . RASSF1A has been shown to be inactivated by promoter methylation in a variety of tumor types [ 16 17 18 19 ] . The 17q21 and 17p13 regions, to which BRCA1 and HIC1 map, respectively, also have been characterized by high frequency of LOH in GCT [ 9 ] . The BRCA 1 gene plays critical roles in DNA repair and recombination, cell cycle checkpoint control, and transcription and has been shown to be hypermethylated in breast-ovarian cancer [ 4 ] . The HIC1 gene is also often hypermethylated in many human cancers [ 20 21 22 ] . The DNA repair gene MGMT encodes O(6)-methylguanine-DNA methyltransferase and this enzyme effectively removes DNA adducts formed by alkylating agents [ 23 ] . Epigenetic inactivation of the MGMT gene was reported in a wide variety of cancers [ 24 25 ] . Also, a low frequency of methylation of the APC , RARB , and FHIT genes was detected in NSGCTs.
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